| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EHA60233.1 | EHA61792.1 | Syn8016DRAFT_2615 | Syn8016DRAFT_1864 | Integral membrane sensor signal transduction histidine kinase; KEGG: ana:alr4878 two-component hybrid sensor and regulator; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SMART: ATPase-like, ATP-binding domain. | PFAM: Adenylate cyclase; KEGG: pmf:P9303_26851 hypothetical protein. | 0.868 |
| EHA60233.1 | EHA61850.1 | Syn8016DRAFT_2615 | Syn8016DRAFT_1922 | Integral membrane sensor signal transduction histidine kinase; KEGG: ana:alr4878 two-component hybrid sensor and regulator; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SMART: ATPase-like, ATP-binding domain. | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.926 |
| EHA60233.1 | EHA61908.1 | Syn8016DRAFT_2615 | Syn8016DRAFT_1980 | Integral membrane sensor signal transduction histidine kinase; KEGG: ana:alr4878 two-component hybrid sensor and regulator; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SMART: ATPase-like, ATP-binding domain. | Adenylate/guanylate cyclase with Chase sensor; KEGG: pmf:P9303_03401 hypothetical protein; PFAM: CHASE2; Adenylyl cyclase class-3/4/guanylyl cyclase; SMART: Adenylyl cyclase class-3/4/guanylyl cyclase. | 0.965 |
| EHA60233.1 | EHA61922.1 | Syn8016DRAFT_2615 | Syn8016DRAFT_1994 | Integral membrane sensor signal transduction histidine kinase; KEGG: ana:alr4878 two-component hybrid sensor and regulator; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SMART: ATPase-like, ATP-binding domain. | KEGG: ter:Tery_3999 adenylate/guanylate cyclase; PFAM: Adenylyl cyclase class-3/4/guanylyl cyclase; Signal transduction response regulator, receiver domain; SMART: Adenylyl cyclase class-3/4/guanylyl cyclase; Signal transduction response regulator, receiver domain. | 0.995 |
| EHA60233.1 | EHA62027.1 | Syn8016DRAFT_2615 | Syn8016DRAFT_2099 | Integral membrane sensor signal transduction histidine kinase; KEGG: ana:alr4878 two-component hybrid sensor and regulator; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SMART: ATPase-like, ATP-binding domain. | Molybdenum cofactor synthesis domain protein; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | 0.868 |
| EHA60233.1 | EHA63281.1 | Syn8016DRAFT_2615 | Syn8016DRAFT_0322 | Integral membrane sensor signal transduction histidine kinase; KEGG: ana:alr4878 two-component hybrid sensor and regulator; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SMART: ATPase-like, ATP-binding domain. | KEGG: pmt:PMT0793 ribonucleotide reductase (class II); TIGRFAM: Ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent. | 0.801 |
| EHA60233.1 | EHA64183.1 | Syn8016DRAFT_2615 | Syn8016DRAFT_1226 | Integral membrane sensor signal transduction histidine kinase; KEGG: ana:alr4878 two-component hybrid sensor and regulator; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SMART: ATPase-like, ATP-binding domain. | KEGG: pmt:PMT1227 putative GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase. | 0.868 |
| EHA60233.1 | nadK | Syn8016DRAFT_2615 | Syn8016DRAFT_1865 | Integral membrane sensor signal transduction histidine kinase; KEGG: ana:alr4878 two-component hybrid sensor and regulator; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SMART: ATPase-like, ATP-binding domain. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.535 |
| EHA60233.1 | ndk | Syn8016DRAFT_2615 | Syn8016DRAFT_1975 | Integral membrane sensor signal transduction histidine kinase; KEGG: ana:alr4878 two-component hybrid sensor and regulator; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SMART: ATPase-like, ATP-binding domain. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.919 |
| EHA60233.1 | ribBA | Syn8016DRAFT_2615 | Syn8016DRAFT_0455 | Integral membrane sensor signal transduction histidine kinase; KEGG: ana:alr4878 two-component hybrid sensor and regulator; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SMART: ATPase-like, ATP-binding domain. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.921 |
| EHA61792.1 | EHA60233.1 | Syn8016DRAFT_1864 | Syn8016DRAFT_2615 | PFAM: Adenylate cyclase; KEGG: pmf:P9303_26851 hypothetical protein. | Integral membrane sensor signal transduction histidine kinase; KEGG: ana:alr4878 two-component hybrid sensor and regulator; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SMART: ATPase-like, ATP-binding domain. | 0.868 |
| EHA61792.1 | EHA61850.1 | Syn8016DRAFT_1864 | Syn8016DRAFT_1922 | PFAM: Adenylate cyclase; KEGG: pmf:P9303_26851 hypothetical protein. | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.849 |
| EHA61792.1 | EHA61908.1 | Syn8016DRAFT_1864 | Syn8016DRAFT_1980 | PFAM: Adenylate cyclase; KEGG: pmf:P9303_26851 hypothetical protein. | Adenylate/guanylate cyclase with Chase sensor; KEGG: pmf:P9303_03401 hypothetical protein; PFAM: CHASE2; Adenylyl cyclase class-3/4/guanylyl cyclase; SMART: Adenylyl cyclase class-3/4/guanylyl cyclase. | 0.849 |
| EHA61792.1 | EHA61922.1 | Syn8016DRAFT_1864 | Syn8016DRAFT_1994 | PFAM: Adenylate cyclase; KEGG: pmf:P9303_26851 hypothetical protein. | KEGG: ter:Tery_3999 adenylate/guanylate cyclase; PFAM: Adenylyl cyclase class-3/4/guanylyl cyclase; Signal transduction response regulator, receiver domain; SMART: Adenylyl cyclase class-3/4/guanylyl cyclase; Signal transduction response regulator, receiver domain. | 0.815 |
| EHA61792.1 | EHA62027.1 | Syn8016DRAFT_1864 | Syn8016DRAFT_2099 | PFAM: Adenylate cyclase; KEGG: pmf:P9303_26851 hypothetical protein. | Molybdenum cofactor synthesis domain protein; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | 0.849 |
| EHA61792.1 | EHA63281.1 | Syn8016DRAFT_1864 | Syn8016DRAFT_0322 | PFAM: Adenylate cyclase; KEGG: pmf:P9303_26851 hypothetical protein. | KEGG: pmt:PMT0793 ribonucleotide reductase (class II); TIGRFAM: Ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent. | 0.849 |
| EHA61792.1 | EHA64183.1 | Syn8016DRAFT_1864 | Syn8016DRAFT_1226 | PFAM: Adenylate cyclase; KEGG: pmf:P9303_26851 hypothetical protein. | KEGG: pmt:PMT1227 putative GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase. | 0.849 |
| EHA61792.1 | nadK | Syn8016DRAFT_1864 | Syn8016DRAFT_1865 | PFAM: Adenylate cyclase; KEGG: pmf:P9303_26851 hypothetical protein. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.815 |
| EHA61792.1 | ndk | Syn8016DRAFT_1864 | Syn8016DRAFT_1975 | PFAM: Adenylate cyclase; KEGG: pmf:P9303_26851 hypothetical protein. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.849 |
| EHA61792.1 | ribBA | Syn8016DRAFT_1864 | Syn8016DRAFT_0455 | PFAM: Adenylate cyclase; KEGG: pmf:P9303_26851 hypothetical protein. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.868 |