| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| XM1_0134 | cobB | XM1_0134 | XM1_0159 | Conserved protein of unknown function (phosphoribosyltransferase fragment); Homologs of previously reported genes of unknown function. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.484 |
| XM1_0134 | cobB-3 | XM1_0134 | XM1_1840 | Conserved protein of unknown function (phosphoribosyltransferase fragment); Homologs of previously reported genes of unknown function. | Cobyrinic acid A,C-diamide synthase(Cobyrinic acid a,c-diamide synthase CbiA,10-456) Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.484 |
| XM1_0134 | cobJ | XM1_0134 | XM1_1227 | Conserved protein of unknown function (phosphoribosyltransferase fragment); Homologs of previously reported genes of unknown function. | Uncharacterized protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.778 |
| XM1_0134 | cobQ | XM1_0134 | XM1_1221 | Conserved protein of unknown function (phosphoribosyltransferase fragment); Homologs of previously reported genes of unknown function. | Cobyric acid synthase(Cobyric acid synthase CobQ,7-475); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.531 |
| XM1_0134 | cobS | XM1_0134 | XM1_0135 | Conserved protein of unknown function (phosphoribosyltransferase fragment); Homologs of previously reported genes of unknown function. | Putative type I secretion membrane fusion protein, HlyD family; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.508 |
| XM1_0134 | cobT | XM1_0134 | XM1_0133 | Conserved protein of unknown function (phosphoribosyltransferase fragment); Homologs of previously reported genes of unknown function. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.909 |
| XM1_0134 | cobU | XM1_0134 | XM1_0704 | Conserved protein of unknown function (phosphoribosyltransferase fragment); Homologs of previously reported genes of unknown function. | Adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.583 |
| XM1_0136 | cobD | XM1_0136 | XM1_1222 | Putative phosphoglycerate mutase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. | Cobalamin biosynthesis protein CobD(Cobalamin biosynthesis CobD/CbiB,16-315); Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.513 |
| XM1_0136 | cobJ | XM1_0136 | XM1_1227 | Putative phosphoglycerate mutase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. | Uncharacterized protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.567 |
| XM1_0136 | cobQ | XM1_0136 | XM1_1221 | Putative phosphoglycerate mutase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. | Cobyric acid synthase(Cobyric acid synthase CobQ,7-475); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.719 |
| XM1_0136 | cobS | XM1_0136 | XM1_0135 | Putative phosphoglycerate mutase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. | Putative type I secretion membrane fusion protein, HlyD family; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.995 |
| XM1_0136 | cobT | XM1_0136 | XM1_0133 | Putative phosphoglycerate mutase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.981 |
| XM1_0136 | cobU | XM1_0136 | XM1_0704 | Putative phosphoglycerate mutase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. | Adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.808 |
| bluB | cobB | XM1_1861 | XM1_0159 | 5,6-dimethylbenzimidazole synthase(5,6-dimethylbenzimidazole synthase BluB,15-215); Function of strongly homologous gene; enzyme. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.747 |
| bluB | cobB-3 | XM1_1861 | XM1_1840 | 5,6-dimethylbenzimidazole synthase(5,6-dimethylbenzimidazole synthase BluB,15-215); Function of strongly homologous gene; enzyme. | Cobyrinic acid A,C-diamide synthase(Cobyrinic acid a,c-diamide synthase CbiA,10-456) Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.451 |
| bluB | cobD | XM1_1861 | XM1_1222 | 5,6-dimethylbenzimidazole synthase(5,6-dimethylbenzimidazole synthase BluB,15-215); Function of strongly homologous gene; enzyme. | Cobalamin biosynthesis protein CobD(Cobalamin biosynthesis CobD/CbiB,16-315); Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.507 |
| bluB | cobJ | XM1_1861 | XM1_1227 | 5,6-dimethylbenzimidazole synthase(5,6-dimethylbenzimidazole synthase BluB,15-215); Function of strongly homologous gene; enzyme. | Uncharacterized protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.627 |
| bluB | cobQ | XM1_1861 | XM1_1221 | 5,6-dimethylbenzimidazole synthase(5,6-dimethylbenzimidazole synthase BluB,15-215); Function of strongly homologous gene; enzyme. | Cobyric acid synthase(Cobyric acid synthase CobQ,7-475); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.554 |
| bluB | cobS | XM1_1861 | XM1_0135 | 5,6-dimethylbenzimidazole synthase(5,6-dimethylbenzimidazole synthase BluB,15-215); Function of strongly homologous gene; enzyme. | Putative type I secretion membrane fusion protein, HlyD family; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.582 |
| bluB | cobT | XM1_1861 | XM1_0133 | 5,6-dimethylbenzimidazole synthase(5,6-dimethylbenzimidazole synthase BluB,15-215); Function of strongly homologous gene; enzyme. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.992 |