| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| XM1_1841 | pabA | XM1_1841 | XM1_2800 | Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Aminodeoxychorismate synthase, subunit II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.915 |
| XM1_1841 | trpA | XM1_1841 | XM1_1307 | Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Tryptophan synthase alpha chain(Aldolase-type TIM barrel,2-265); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.937 |
| XM1_1841 | trpB | XM1_1841 | XM1_1308 | Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Tryptophan synthase, beta subunit(Tryptophan synthase, beta chain,11-398); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.920 |
| XM1_1841 | trpC | XM1_1841 | XM1_2798 | Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative Indole-3-glycerol phosphate synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the TrpC family. | 0.924 |
| XM1_1841 | trpE | XM1_1841 | XM1_3609 | Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.969 |
| XM1_1841 | trpF | XM1_1841 | XM1_1317 | Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | N-(5'-phosphoribosyl)anthranilate isomerase(Aldolase-type TIM barrel,4-211) Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TrpF family. | 0.928 |
| glyA | trpA | XM1_3121 | XM1_1307 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase alpha chain(Aldolase-type TIM barrel,2-265); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.931 |
| glyA | trpB | XM1_3121 | XM1_1308 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase, beta subunit(Tryptophan synthase, beta chain,11-398); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.935 |
| glyA | trpB-2 | XM1_3121 | XM1_2548 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative Tryptophan synthase beta chain 2; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.904 |
| glyA | trpB-3 | XM1_3121 | XM1_3636 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase beta chain 2; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.904 |
| glyA | trpE | XM1_3121 | XM1_3609 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.453 |
| pabA | XM1_1841 | XM1_2800 | XM1_1841 | Aminodeoxychorismate synthase, subunit II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.915 |
| pabA | trpA | XM1_2800 | XM1_1307 | Aminodeoxychorismate synthase, subunit II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Tryptophan synthase alpha chain(Aldolase-type TIM barrel,2-265); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.983 |
| pabA | trpB | XM1_2800 | XM1_1308 | Aminodeoxychorismate synthase, subunit II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Tryptophan synthase, beta subunit(Tryptophan synthase, beta chain,11-398); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.982 |
| pabA | trpC | XM1_2800 | XM1_2798 | Aminodeoxychorismate synthase, subunit II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Putative Indole-3-glycerol phosphate synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the TrpC family. | 0.999 |
| pabA | trpD | XM1_2800 | XM1_2799 | Aminodeoxychorismate synthase, subunit II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.999 |
| pabA | trpE | XM1_2800 | XM1_3609 | Aminodeoxychorismate synthase, subunit II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.999 |
| pabA | trpF | XM1_2800 | XM1_1317 | Aminodeoxychorismate synthase, subunit II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | N-(5'-phosphoribosyl)anthranilate isomerase(Aldolase-type TIM barrel,4-211) Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TrpF family. | 0.998 |
| trpA | XM1_1841 | XM1_1307 | XM1_1841 | Tryptophan synthase alpha chain(Aldolase-type TIM barrel,2-265); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.937 |
| trpA | glyA | XM1_1307 | XM1_3121 | Tryptophan synthase alpha chain(Aldolase-type TIM barrel,2-265); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.931 |