| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| XM1_1379 | metX | XM1_1379 | XM1_1378 | Putative SAM-dependent methyltransferase(Methionine biosynthesis MetW,10-204); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. | 0.998 |
| XM1_4591 | hom | XM1_4591 | XM1_1596 | Putative O-acetylhomoserine (thiol)-lyase (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Homoserine dehydrogenase(NAD(P)-binding domain,4-150;Homoserine dehydrogenase, catalytic139-317); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.866 |
| XM1_4591 | metX | XM1_4591 | XM1_1378 | Putative O-acetylhomoserine (thiol)-lyase (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. | 0.974 |
| XM1_4591 | metZ | XM1_4591 | XM1_0395 | Putative O-acetylhomoserine (thiol)-lyase (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.940 |
| XM1_4591 | oahs | XM1_4591 | XM1_3371 | Putative O-acetylhomoserine (thiol)-lyase (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | O-acetylhomoserine (thiol)-lyase; Function of strongly homologous gene; enzyme. | 0.910 |
| agxt | glyA | XM1_0741 | XM1_3121 | Serine--pyruvate aminotransferase; Function of strongly homologous gene; enzyme. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.924 |
| agxt | metX | XM1_0741 | XM1_1378 | Serine--pyruvate aminotransferase; Function of strongly homologous gene; enzyme. | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. | 0.800 |
| agxt | pssA | XM1_0741 | XM1_0217 | Serine--pyruvate aminotransferase; Function of strongly homologous gene; enzyme. | CDP-diacylglycerol--serine O-phosphatidyltransferase; Function of strongly homologous gene; enzyme; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
| agxt | serB | XM1_0741 | XM1_1654 | Serine--pyruvate aminotransferase; Function of strongly homologous gene; enzyme. | Phosphoserine phosphatase(Phosphoserine phosphatase SerB,78-287); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.920 |
| agxt | trpB | XM1_0741 | XM1_1308 | Serine--pyruvate aminotransferase; Function of strongly homologous gene; enzyme. | Tryptophan synthase, beta subunit(Tryptophan synthase, beta chain,11-398); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.907 |
| glyA | agxt | XM1_3121 | XM1_0741 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Serine--pyruvate aminotransferase; Function of strongly homologous gene; enzyme. | 0.924 |
| glyA | metX | XM1_3121 | XM1_1378 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. | 0.837 |
| glyA | pssA | XM1_3121 | XM1_0217 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | CDP-diacylglycerol--serine O-phosphatidyltransferase; Function of strongly homologous gene; enzyme; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.902 |
| glyA | serB | XM1_3121 | XM1_1654 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoserine phosphatase(Phosphoserine phosphatase SerB,78-287); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.948 |
| glyA | trpB | XM1_3121 | XM1_1308 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase, beta subunit(Tryptophan synthase, beta chain,11-398); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.935 |
| hom | XM1_4591 | XM1_1596 | XM1_4591 | Homoserine dehydrogenase(NAD(P)-binding domain,4-150;Homoserine dehydrogenase, catalytic139-317); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Putative O-acetylhomoserine (thiol)-lyase (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.866 |
| hom | metX | XM1_1596 | XM1_1378 | Homoserine dehydrogenase(NAD(P)-binding domain,4-150;Homoserine dehydrogenase, catalytic139-317); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. | 0.957 |
| hom | metZ | XM1_1596 | XM1_0395 | Homoserine dehydrogenase(NAD(P)-binding domain,4-150;Homoserine dehydrogenase, catalytic139-317); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.896 |
| hom | oahs | XM1_1596 | XM1_3371 | Homoserine dehydrogenase(NAD(P)-binding domain,4-150;Homoserine dehydrogenase, catalytic139-317); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | O-acetylhomoserine (thiol)-lyase; Function of strongly homologous gene; enzyme. | 0.866 |
| metX | XM1_1379 | XM1_1378 | XM1_1379 | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. | Putative SAM-dependent methyltransferase(Methionine biosynthesis MetW,10-204); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.998 |