| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| XM1_0435 | folK | XM1_0435 | XM1_3358 | Putative tRNA nucleotidyltransferase/poly(A) polymerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.762 |
| XM1_0435 | ribD | XM1_0435 | XM1_3123 | Putative tRNA nucleotidyltransferase/poly(A) polymerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.593 |
| XM1_3357 | XM1_3360 | XM1_3357 | XM1_3360 | Protein of unknown function; No homology to any previously reported sequences. | Dihydroneopterin aldolase; Function of strongly homologous gene; enzyme. | 0.464 |
| XM1_3357 | folK | XM1_3357 | XM1_3358 | Protein of unknown function; No homology to any previously reported sequences. | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.774 |
| XM1_3360 | XM1_3357 | XM1_3360 | XM1_3357 | Dihydroneopterin aldolase; Function of strongly homologous gene; enzyme. | Protein of unknown function; No homology to any previously reported sequences. | 0.464 |
| XM1_3360 | XM1_3723 | XM1_3360 | XM1_3723 | Dihydroneopterin aldolase; Function of strongly homologous gene; enzyme. | Tetrahydromethanopterin S-methyltransferase (fragment); Function of strongly homologous gene; enzyme. | 0.882 |
| XM1_3360 | folC | XM1_3360 | XM1_1303 | Dihydroneopterin aldolase; Function of strongly homologous gene; enzyme. | Bifunctional folylpolyglutamate synthase and dihydrofolate synthase; Function of strongly homologous gene; putative enzyme; Belongs to the folylpolyglutamate synthase family. | 0.672 |
| XM1_3360 | folE | XM1_3360 | XM1_0397 | Dihydroneopterin aldolase; Function of strongly homologous gene; enzyme. | GTP cyclohydrolase 1; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.941 |
| XM1_3360 | folK | XM1_3360 | XM1_3358 | Dihydroneopterin aldolase; Function of strongly homologous gene; enzyme. | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.996 |
| XM1_3360 | folP | XM1_3360 | XM1_4116 | Dihydroneopterin aldolase; Function of strongly homologous gene; enzyme. | Dihydropteroate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.992 |
| XM1_3360 | ispDF | XM1_3360 | XM1_3146 | Dihydroneopterin aldolase; Function of strongly homologous gene; enzyme. | Bifunctional enzyme IspD/IspF [Includes: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). | 0.639 |
| XM1_3360 | ribB | XM1_3360 | XM1_3125 | Dihydroneopterin aldolase; Function of strongly homologous gene; enzyme. | Riboflavin biosynthesis protein RibBA [Includes: 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.501 |
| XM1_3360 | ribD | XM1_3360 | XM1_3123 | Dihydroneopterin aldolase; Function of strongly homologous gene; enzyme. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.703 |
| XM1_3723 | XM1_3360 | XM1_3723 | XM1_3360 | Tetrahydromethanopterin S-methyltransferase (fragment); Function of strongly homologous gene; enzyme. | Dihydroneopterin aldolase; Function of strongly homologous gene; enzyme. | 0.882 |
| XM1_3723 | folC | XM1_3723 | XM1_1303 | Tetrahydromethanopterin S-methyltransferase (fragment); Function of strongly homologous gene; enzyme. | Bifunctional folylpolyglutamate synthase and dihydrofolate synthase; Function of strongly homologous gene; putative enzyme; Belongs to the folylpolyglutamate synthase family. | 0.538 |
| XM1_3723 | folE | XM1_3723 | XM1_0397 | Tetrahydromethanopterin S-methyltransferase (fragment); Function of strongly homologous gene; enzyme. | GTP cyclohydrolase 1; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.882 |
| XM1_3723 | folK | XM1_3723 | XM1_3358 | Tetrahydromethanopterin S-methyltransferase (fragment); Function of strongly homologous gene; enzyme. | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.882 |
| XM1_3723 | ribB | XM1_3723 | XM1_3125 | Tetrahydromethanopterin S-methyltransferase (fragment); Function of strongly homologous gene; enzyme. | Riboflavin biosynthesis protein RibBA [Includes: 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.457 |
| XM1_3723 | ribD | XM1_3723 | XM1_3123 | Tetrahydromethanopterin S-methyltransferase (fragment); Function of strongly homologous gene; enzyme. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.610 |
| folC | XM1_3360 | XM1_1303 | XM1_3360 | Bifunctional folylpolyglutamate synthase and dihydrofolate synthase; Function of strongly homologous gene; putative enzyme; Belongs to the folylpolyglutamate synthase family. | Dihydroneopterin aldolase; Function of strongly homologous gene; enzyme. | 0.672 |