node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
birA | hrcA | ERS852572_02583 | ERS852572_00074 | Bifunctional protein BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.566 |
birA | perR | ERS852572_02583 | ERS852572_01003 | Bifunctional protein BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Peroxide-responsive repressor perR; Belongs to the Fur family. | 0.534 |
birA | rpoA | ERS852572_02583 | ERS852572_02875 | Bifunctional protein BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.596 |
cspA | fliM | ERS852572_00063 | ERS852572_02387 | Cold shock protein CspA. | Flagellar motor switch protein FliM. | 0.521 |
cspA | grpE | ERS852572_00063 | ERS852572_00075 | Cold shock protein CspA. | HSP-70 cofactor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependen [...] | 0.712 |
cspA | hrcA | ERS852572_00063 | ERS852572_00074 | Cold shock protein CspA. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.825 |
cspA | perR | ERS852572_00063 | ERS852572_01003 | Cold shock protein CspA. | Peroxide-responsive repressor perR; Belongs to the Fur family. | 0.754 |
cspA | rpoA | ERS852572_00063 | ERS852572_02875 | Cold shock protein CspA. | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.772 |
cspA | sigD | ERS852572_00063 | ERS852572_02405 | Cold shock protein CspA. | Sigma-28; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 0.730 |
def1 | perR | ERS852572_00938 | ERS852572_01003 | Peptide deformylase 1; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | Peroxide-responsive repressor perR; Belongs to the Fur family. | 0.576 |
fliM | cspA | ERS852572_02387 | ERS852572_00063 | Flagellar motor switch protein FliM. | Cold shock protein CspA. | 0.521 |
fliM | grpE | ERS852572_02387 | ERS852572_00075 | Flagellar motor switch protein FliM. | HSP-70 cofactor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependen [...] | 0.627 |
fliM | hrcA | ERS852572_02387 | ERS852572_00074 | Flagellar motor switch protein FliM. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.595 |
fliM | perR | ERS852572_02387 | ERS852572_01003 | Flagellar motor switch protein FliM. | Peroxide-responsive repressor perR; Belongs to the Fur family. | 0.517 |
fliM | rbr3A | ERS852572_02387 | ERS852572_01004 | Flagellar motor switch protein FliM. | NADH peroxidase. | 0.420 |
fliM | sigD | ERS852572_02387 | ERS852572_02405 | Flagellar motor switch protein FliM. | Sigma-28; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 0.983 |
grpE | cspA | ERS852572_00075 | ERS852572_00063 | HSP-70 cofactor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependen [...] | Cold shock protein CspA. | 0.712 |
grpE | fliM | ERS852572_00075 | ERS852572_02387 | HSP-70 cofactor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependen [...] | Flagellar motor switch protein FliM. | 0.627 |
grpE | hrcA | ERS852572_00075 | ERS852572_00074 | HSP-70 cofactor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependen [...] | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.996 |
grpE | perR | ERS852572_00075 | ERS852572_01003 | HSP-70 cofactor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependen [...] | Peroxide-responsive repressor perR; Belongs to the Fur family. | 0.539 |