STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dnaG_3DNA primase. (206 aa)    
Predicted Functional Partners:
CUN23483.1
Phage/plasmid primase%2C P4 family%2C C-terminal domain.
 
   
 0.938
CUN23474.1
Plasmid recombination enzyme.
 
    0.819
dnaC_2
Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.
  
 
 0.818
CUN28189.1
Phage/plasmid primase%2C P4 family%2C C-terminal domain.
 
   
 0.721
CUN23508.1
Acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase.
 
    0.586
CUN23516.1
Uncharacterised protein.
  
  
 0.581
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.545
sigA
Sigma-A; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
  
  
 0.517
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
  
 0.490
CUN23503.1
Uncharacterised protein.
       0.481
Your Current Organism:
Roseburia intestinalis
NCBI taxonomy Id: 166486
Other names: DSM 14610, NCIMB 13810, R. intestinalis, Roseburia intestinalis Duncan et al. 2002 emend. Duncan et al. 2006, strain L1-82
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.