STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tmkThymidylate kinase. (207 aa)    
Predicted Functional Partners:
CPM_1941
Ribonucleoside-diphosphate reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
  
 
 0.952
CPM_1384
Deoxycytidylate deaminase.
    
 0.946
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
  
 
 0.941
thiI
tRNA S(4)U 4-thiouridine synthase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
       0.769
CPM_0522
Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase.
  
  
 0.734
CPM_0437
Replication factor C large subunit.
  
 
 0.719
CPM_1739
Replication factor C small subunit.
  
 
 0.719
CPM_1376
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
 
   
 0.643
rnhB
Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.
 
    0.607
serS
seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec).
 
    0.598
Your Current Organism:
Cuniculiplasma divulgatum
NCBI taxonomy Id: 1673428
Other names: C. divulgatum, Cuniculiplasma divulgatum Golyshina et al. 2016, JCM 30642, Thermoplasmatales archaeon PM4, Thermoplasmatales archaeon S5, VKM B-2941, strain S5
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