node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CPS_0838 | CPS_1131 | CPS_0838 | CPS_1131 | Aminotransferase, class V; Identified by similarity to SP:P55690; match to protein family HMM PF00266. | Rrf2 family protein; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.839 |
CPS_0838 | CPS_1134 | CPS_0838 | CPS_1134 | Aminotransferase, class V; Identified by similarity to SP:P55690; match to protein family HMM PF00266. | Iron-sulfur cluster assembly protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | 0.693 |
CPS_0838 | CPS_1137 | CPS_0838 | CPS_1137 | Aminotransferase, class V; Identified by similarity to SP:P55690; match to protein family HMM PF00266. | Ferredoxin, 2Fe-2S; Identified by match to protein family HMM PF00111; match to protein family HMM TIGR02007. | 0.703 |
CPS_0838 | CPS_1201 | CPS_0838 | CPS_1201 | Aminotransferase, class V; Identified by similarity to SP:P55690; match to protein family HMM PF00266. | Ferredoxin, 4Fe-4S; Identified by match to protein family HMM PF00037. | 0.456 |
CPS_0838 | CPS_4263 | CPS_0838 | CPS_4263 | Aminotransferase, class V; Identified by similarity to SP:P55690; match to protein family HMM PF00266. | Conserved hypothetical protein; Identified by similarity to OMNI:SO2271; match to protein family HMM PF04384. | 0.579 |
CPS_0838 | cyaY | CPS_0838 | CPS_0075 | Aminotransferase, class V; Identified by similarity to SP:P55690; match to protein family HMM PF00266. | cyaY protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | 0.929 |
CPS_0838 | hscA | CPS_0838 | CPS_1136 | Aminotransferase, class V; Identified by similarity to SP:P55690; match to protein family HMM PF00266. | Chaperone protein HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. | 0.674 |
CPS_0838 | hscB | CPS_0838 | CPS_1135 | Aminotransferase, class V; Identified by similarity to SP:P55690; match to protein family HMM PF00266. | Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.661 |
CPS_0838 | iscS | CPS_0838 | CPS_1132 | Aminotransferase, class V; Identified by similarity to SP:P55690; match to protein family HMM PF00266. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.943 |
CPS_0838 | iscU | CPS_0838 | CPS_1133 | Aminotransferase, class V; Identified by similarity to SP:P55690; match to protein family HMM PF00266. | Iron-sulfur cluster assembly protein IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.990 |
CPS_1131 | CPS_0838 | CPS_1131 | CPS_0838 | Rrf2 family protein; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Aminotransferase, class V; Identified by similarity to SP:P55690; match to protein family HMM PF00266. | 0.839 |
CPS_1131 | CPS_1134 | CPS_1131 | CPS_1134 | Rrf2 family protein; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Iron-sulfur cluster assembly protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | 0.831 |
CPS_1131 | CPS_1137 | CPS_1131 | CPS_1137 | Rrf2 family protein; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Ferredoxin, 2Fe-2S; Identified by match to protein family HMM PF00111; match to protein family HMM TIGR02007. | 0.593 |
CPS_1131 | hscA | CPS_1131 | CPS_1136 | Rrf2 family protein; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Chaperone protein HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. | 0.427 |
CPS_1131 | hscB | CPS_1131 | CPS_1135 | Rrf2 family protein; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.890 |
CPS_1131 | iscS | CPS_1131 | CPS_1132 | Rrf2 family protein; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.996 |
CPS_1131 | iscU | CPS_1131 | CPS_1133 | Rrf2 family protein; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Iron-sulfur cluster assembly protein IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.958 |
CPS_1134 | CPS_0838 | CPS_1134 | CPS_0838 | Iron-sulfur cluster assembly protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | Aminotransferase, class V; Identified by similarity to SP:P55690; match to protein family HMM PF00266. | 0.693 |
CPS_1134 | CPS_1131 | CPS_1134 | CPS_1131 | Iron-sulfur cluster assembly protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | Rrf2 family protein; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.831 |
CPS_1134 | CPS_1137 | CPS_1134 | CPS_1137 | Iron-sulfur cluster assembly protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | Ferredoxin, 2Fe-2S; Identified by match to protein family HMM PF00111; match to protein family HMM TIGR02007. | 0.934 |