node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CPS_2813 | megL | CPS_2813 | CPS_1705 | Conserved hypothetical protein; Identified by similarity to OMNI:NTL03EC2549. | Methionine gamma-lyase; Identified by match to protein family HMM PF01053; match to protein family HMM TIGR01328. | 0.901 |
CPS_2813 | metE | CPS_2813 | CPS_1151 | Conserved hypothetical protein; Identified by similarity to OMNI:NTL03EC2549. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Identified by similarity to GP:13540428; match to protein family HMM PF01717. | 0.900 |
CPS_2813 | metH | CPS_2813 | CPS_1101 | Conserved hypothetical protein; Identified by similarity to OMNI:NTL03EC2549. | 5-methyltetrahydrofolate--homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.900 |
CPS_2813 | metK | CPS_2813 | CPS_1256 | Conserved hypothetical protein; Identified by similarity to OMNI:NTL03EC2549. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.900 |
coaBC | metK | CPS_0182 | CPS_1256 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.776 |
guaA | metH | CPS_4241 | CPS_1101 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 5-methyltetrahydrofolate--homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.499 |
guaA | metK | CPS_4241 | CPS_1256 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.836 |
guaA | metL | CPS_4241 | CPS_0456 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Aspartokinase/homoserine dehydrogenase II; Identified by similarity to SP:P00562; match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF03447; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.481 |
ispF | metK | CPS_1073 | CPS_1256 | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.807 |
megL | CPS_2813 | CPS_1705 | CPS_2813 | Methionine gamma-lyase; Identified by match to protein family HMM PF01053; match to protein family HMM TIGR01328. | Conserved hypothetical protein; Identified by similarity to OMNI:NTL03EC2549. | 0.901 |
megL | metE | CPS_1705 | CPS_1151 | Methionine gamma-lyase; Identified by match to protein family HMM PF01053; match to protein family HMM TIGR01328. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Identified by similarity to GP:13540428; match to protein family HMM PF01717. | 0.949 |
megL | metH | CPS_1705 | CPS_1101 | Methionine gamma-lyase; Identified by match to protein family HMM PF01053; match to protein family HMM TIGR01328. | 5-methyltetrahydrofolate--homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.970 |
megL | metK | CPS_1705 | CPS_1256 | Methionine gamma-lyase; Identified by match to protein family HMM PF01053; match to protein family HMM TIGR01328. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.921 |
megL | metL | CPS_1705 | CPS_0456 | Methionine gamma-lyase; Identified by match to protein family HMM PF01053; match to protein family HMM TIGR01328. | Aspartokinase/homoserine dehydrogenase II; Identified by similarity to SP:P00562; match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF03447; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.725 |
metE | CPS_2813 | CPS_1151 | CPS_2813 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Identified by similarity to GP:13540428; match to protein family HMM PF01717. | Conserved hypothetical protein; Identified by similarity to OMNI:NTL03EC2549. | 0.900 |
metE | megL | CPS_1151 | CPS_1705 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Identified by similarity to GP:13540428; match to protein family HMM PF01717. | Methionine gamma-lyase; Identified by match to protein family HMM PF01053; match to protein family HMM TIGR01328. | 0.949 |
metE | metH | CPS_1151 | CPS_1101 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Identified by similarity to GP:13540428; match to protein family HMM PF01717. | 5-methyltetrahydrofolate--homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.984 |
metE | metK | CPS_1151 | CPS_1256 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Identified by similarity to GP:13540428; match to protein family HMM PF01717. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.987 |
metE | metL | CPS_1151 | CPS_0456 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Identified by similarity to GP:13540428; match to protein family HMM PF01717. | Aspartokinase/homoserine dehydrogenase II; Identified by similarity to SP:P00562; match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF03447; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.955 |
metH | CPS_2813 | CPS_1101 | CPS_2813 | 5-methyltetrahydrofolate--homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Conserved hypothetical protein; Identified by similarity to OMNI:NTL03EC2549. | 0.900 |