CPS_2497 protein (Colwellia psychrerythraea)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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Score

CPS_2497

Conserved hypothetical protein; Identified by similarity to OMNI:CC2071. (204 aa)

Predicted Functional Partners:

CPS_2496

0.658

CPS_2495

0.589

CPS_3994

0.506

CPS_4420

0.489

CPS_2498

0.486

CPS_0410

0.415

CPS_3694

0.414

Your Current Organism:

Colwellia psychrerythraea

NCBI taxonomy Id: 167879
Other names: C. psychrerythraea 34H, Colwellia psychrerythraea 34H, Colwellia psychrerythraea str. 34H, Colwellia psychrerythraea strain 34H, Colwellia sp. 34H

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
CPS_0410	CPS_2497	Hypothetical protein; Identified by Glimmer2; putative.	Conserved hypothetical protein; Identified by similarity to OMNI:CC2071.	0.415
CPS_0410	CPS_3694	Hypothetical protein; Identified by Glimmer2; putative.	Hypothetical protein; Identified by Glimmer2; putative.	0.579
CPS_0410	CPS_4420	Hypothetical protein; Identified by Glimmer2; putative.	TonB-dependent receptor; Identified by match to protein family HMM PF00593; match to protein family HMM PF07715.	0.412
CPS_2495	CPS_2496	Putative glutathione S-transferase; Identified by match to protein family HMM PF00043; match to protein family HMM PF02798; Belongs to the GST superfamily.	Hypothetical protein; Identified by Glimmer2; putative.	0.543
CPS_2495	CPS_2497	Putative glutathione S-transferase; Identified by match to protein family HMM PF00043; match to protein family HMM PF02798; Belongs to the GST superfamily.	Conserved hypothetical protein; Identified by similarity to OMNI:CC2071.	0.589
CPS_2496	CPS_2495	Hypothetical protein; Identified by Glimmer2; putative.	Putative glutathione S-transferase; Identified by match to protein family HMM PF00043; match to protein family HMM PF02798; Belongs to the GST superfamily.	0.543
CPS_2496	CPS_2497	Hypothetical protein; Identified by Glimmer2; putative.	Conserved hypothetical protein; Identified by similarity to OMNI:CC2071.	0.658
CPS_2496	CPS_2498	Hypothetical protein; Identified by Glimmer2; putative.	Conserved hypothetical protein; Identified by similarity to OMNI:SO1615.	0.422
CPS_2497	CPS_0410	Conserved hypothetical protein; Identified by similarity to OMNI:CC2071.	Hypothetical protein; Identified by Glimmer2; putative.	0.415
CPS_2497	CPS_2495	Conserved hypothetical protein; Identified by similarity to OMNI:CC2071.	Putative glutathione S-transferase; Identified by match to protein family HMM PF00043; match to protein family HMM PF02798; Belongs to the GST superfamily.	0.589
CPS_2497	CPS_2496	Conserved hypothetical protein; Identified by similarity to OMNI:CC2071.	Hypothetical protein; Identified by Glimmer2; putative.	0.658
CPS_2497	CPS_2498	Conserved hypothetical protein; Identified by similarity to OMNI:CC2071.	Conserved hypothetical protein; Identified by similarity to OMNI:SO1615.	0.486
CPS_2497	CPS_3694	Conserved hypothetical protein; Identified by similarity to OMNI:CC2071.	Hypothetical protein; Identified by Glimmer2; putative.	0.414
CPS_2497	CPS_3994	Conserved hypothetical protein; Identified by similarity to OMNI:CC2071.	Putative lipoprotein.	0.506
CPS_2497	CPS_4420	Conserved hypothetical protein; Identified by similarity to OMNI:CC2071.	TonB-dependent receptor; Identified by match to protein family HMM PF00593; match to protein family HMM PF07715.	0.489
CPS_2498	CPS_2496	Conserved hypothetical protein; Identified by similarity to OMNI:SO1615.	Hypothetical protein; Identified by Glimmer2; putative.	0.422
CPS_2498	CPS_2497	Conserved hypothetical protein; Identified by similarity to OMNI:SO1615.	Conserved hypothetical protein; Identified by similarity to OMNI:CC2071.	0.486
CPS_3694	CPS_0410	Hypothetical protein; Identified by Glimmer2; putative.	Hypothetical protein; Identified by Glimmer2; putative.	0.579
CPS_3694	CPS_2497	Hypothetical protein; Identified by Glimmer2; putative.	Conserved hypothetical protein; Identified by similarity to OMNI:CC2071.	0.414
CPS_3994	CPS_2497	Putative lipoprotein.	Conserved hypothetical protein; Identified by similarity to OMNI:CC2071.	0.506

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.802

expected number of edges:

11

PPI enrichment p-value:

2.54e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045638

Negative regulation of myeloid cell differentiation

4 of 65

2.05

1.87

0.00019

GO:0045637

Regulation of myeloid cell differentiation

5 of 151

1.78

1.81

0.00012

GO:0045596

Negative regulation of cell differentiation

6 of 451

1.39

0.00019

GO:0007389

Pattern specification process

5 of 328

1.45

1.36

0.00039

GO:0009880

Embryonic pattern specification

3 of 55

2.0

1.34

0.0025

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000978

RNA polymerase II cis-regulatory region sequence-specific DNA binding

9 of 969

1.23

1.66

1.06e-07

GO:0003700

DNA-binding transcription factor activity

10 of 1187

1.19

1.64

1.60e-08

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

5 of 326

1.45

1.52

0.00010

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

9 of 1118

1.17

1.51

1.51e-07

GO:0003677

DNA binding

10 of 2214

0.92

1.0

6.34e-07

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:22829811

(2012) Epigenetic alterations in bladder cancer and their potential clinical implications.

4 of 17

2.64

2.58

1.63e-05

PMID:22495965

(2012) A novel 13 base pair insertion in the sonic hedgehog ZRS limb enhancer (ZRSLMBR1) causes preaxial polydactyly with triphalangeal thumb.

3 of 9

2.79

1.71

0.00076

PMID:26572684

(2015) Transcriptome profiling reveals distinctive traits of retinol metabolism and neonatal parallels in the MRLMpJ mouse.

3 of 11

2.7

1.68

0.00084

PMID:36418415

(2022) The autism-associated Meis2 gene is necessary for cardiac baroreflex regulation in mice.

3 of 13

2.63

1.64

0.00097

PMID:28874668

(2017) Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation.

3 of 19

2.46

1.45

0.0021

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:26589

Embryonic skeletal system morphogenesis, and N-terminal of Homeobox Meis and PKNOX1

6 of 25

2.64

5.58

1.61e-11

CL:26624

Mixed, incl. Protein of unknown function (DUF3528), and N-terminal of Homeobox Meis and PKNOX1

4 of 5

3.17

4.61

3.85e-09

CL:26433

Homeobox, and Neuron fate commitment

7 of 125

2.01

4.2

1.26e-10

CL:32174

Mixed, incl. Adiponectin binding, and G2 nidogen domain and fibulin

2 of 7

2.72

1.24

0.0055

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cfa05202

Transcriptional misregulation in cancer

4 of 141

1.72

1.63

0.00027

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005634

Nucleus

9 of 3900

0.63

0.4

0.0259

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0371

Homeobox

7 of 203

1.8

3.38

1.55e-09

KW-0238

DNA-binding

8 of 642

1.36

2.01

3.42e-08

KW-0539

Nucleus

8 of 1146

1.11

1.29

2.14e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16493

N-terminal of Homeobox Meis and PKNOX1

2 of 5

2.87

1.04

0.0130

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00389

Homeodomain

7 of 208

1.79

3.25

3.60e-09

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