GAP43165.1 protein (Lentimicrobium saccharophilum)

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

GAP43165.1

Iron only hydrogenase large subunit, C-terminal domain. (574 aa)

Predicted Functional Partners:

GAP43155.1

0.993

GAP42698.1

0.973

GAP44921.1

0.969

GAP43164.1

0.949

GAP43163.1

0.872

GAP44919.1

0.863

GAP43162.1

0.852

GAP43166.1

0.852

GAP44917.1

0.785

GAP44903.1

0.766

Your Current Organism:

Lentimicrobium saccharophilum

NCBI taxonomy Id: 1678841
Other names: Bacteroidales bacterium TBC1, DSM 100618, JCM 30898, L. saccharophilum, Lentimicrobium saccharophilum Sun et al. 2016, strain TBC1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GAP42698.1	GAP43155.1	TBC1_11835	TBC1_111297	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit.	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit.	0.966
GAP42698.1	GAP43162.1	TBC1_11835	TBC1_111304	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit.	[FeFe] hydrogenase, group B1/B3.	0.973
GAP42698.1	GAP43163.1	TBC1_11835	TBC1_111305	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit.	Thioredoxin-like [2Fe-2S] ferredoxin.	0.993
GAP42698.1	GAP43165.1	TBC1_11835	TBC1_111307	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit.	Iron only hydrogenase large subunit, C-terminal domain.	0.973
GAP42698.1	GAP43166.1	TBC1_11835	TBC1_111308	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit.	Thioredoxin-like [2Fe-2S] ferredoxin.	0.993
GAP42698.1	GAP44903.1	TBC1_11835	TBC1_12717	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit.	Protein containing 4Fe-4S dicluster domain.	0.994
GAP42698.1	GAP44919.1	TBC1_11835	TBC1_12733	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit.	Thioredoxin-like [2Fe-2S] ferredoxin.	0.993
GAP42698.1	GAP44921.1	TBC1_11835	TBC1_12735	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit.	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit.	0.996
GAP43155.1	GAP42698.1	TBC1_111297	TBC1_11835	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit.	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit.	0.966
GAP43155.1	GAP43162.1	TBC1_111297	TBC1_111304	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit.	[FeFe] hydrogenase, group B1/B3.	0.993
GAP43155.1	GAP43163.1	TBC1_111297	TBC1_111305	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit.	Thioredoxin-like [2Fe-2S] ferredoxin.	0.999
GAP43155.1	GAP43165.1	TBC1_111297	TBC1_111307	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit.	Iron only hydrogenase large subunit, C-terminal domain.	0.993
GAP43155.1	GAP43166.1	TBC1_111297	TBC1_111308	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit.	Thioredoxin-like [2Fe-2S] ferredoxin.	0.999
GAP43155.1	GAP44903.1	TBC1_111297	TBC1_12717	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit.	Protein containing 4Fe-4S dicluster domain.	0.998
GAP43155.1	GAP44919.1	TBC1_111297	TBC1_12733	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit.	Thioredoxin-like [2Fe-2S] ferredoxin.	0.999
GAP43155.1	GAP44921.1	TBC1_111297	TBC1_12735	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit.	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit.	0.995
GAP43162.1	GAP42698.1	TBC1_111304	TBC1_11835	[FeFe] hydrogenase, group B1/B3.	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit.	0.973
GAP43162.1	GAP43155.1	TBC1_111304	TBC1_111297	[FeFe] hydrogenase, group B1/B3.	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit.	0.993
GAP43162.1	GAP43163.1	TBC1_111304	TBC1_111305	[FeFe] hydrogenase, group B1/B3.	Thioredoxin-like [2Fe-2S] ferredoxin.	0.873
GAP43162.1	GAP43164.1	TBC1_111304	TBC1_111306	[FeFe] hydrogenase, group B1/B3.	Stage II sporulation protein E.	0.915

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Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

43

PPI enrichment p-value:

0.0308

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016925

Protein sumoylation

3 of 10

2.89

3.22

2.70e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008641

Ubiquitin-like modifier activating enzyme activity

2 of 8

2.81

1.5

0.0079

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031510

SUMO activating enzyme complex

2 of 2

3.41

2.34

0.00057

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:967

SUMO is conjugated to E1 (UBA2:SAE1), and deSUMOylase activity

3 of 7

3.04

3.71

5.94e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04120

Ubiquitin mediated proteolysis

3 of 110

1.85

1.8

0.00097

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3065678

SUMO is transferred from E1 to E2 (UBE2I, UBC9)

4 of 29

2.55

4.5

1.65e-07

MAP-3215018

Processing and activation of SUMO

4 of 32

2.51

4.46

1.65e-07

MAP-2990846

SUMOylation

4 of 132

1.89

2.64

1.83e-05

MAP-3065676

SUMO is conjugated to E1 (UBA2:SAE1)

2 of 4

3.11

2.42

0.00042

MAP-597592

Post-translational protein modification

4 of 667

1.19

0.93

0.0065

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031510

SUMO activating enzyme complex

2 of 2

3.41

2.28

0.00069

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045886

ThiF/MoeB/HesA family

2 of 8

2.81

1.31

0.0149

IPR035985

Ubiquitin-activating enzyme

2 of 8

2.81

1.31

0.0149

IPR000594

THIF-type NAD/FAD binding fold

2 of 8

2.81

1.31

0.0149

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