GAP44080.1 protein (Lentimicrobium saccharophilum)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:

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Score

GAP44080.1

ABC-type multidrug transport system, ATPase component. (245 aa)

Predicted Functional Partners:

GAP44081.1

0.994

GAP44082.1

0.993

GAP44077.1

0.918

TBC1_1238

0.904

GAP45139.1

0.902

GAP44076.1

0.895

GAP44075.1

0.838

GAP44079.1

0.796

GAP42124.1

0.793

GAP44078.1

0.773

Your Current Organism:

Lentimicrobium saccharophilum

NCBI taxonomy Id: 1678841
Other names: Bacteroidales bacterium TBC1, DSM 100618, JCM 30898, L. saccharophilum, Lentimicrobium saccharophilum Sun et al. 2016, strain TBC1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GAP42124.1	GAP44077.1	TBC1_11253	TBC1_112238	ABC-type multidrug transport system, permease component.	hlyD family secretion protein.	0.647
GAP42124.1	GAP44079.1	TBC1_11253	TBC1_112240	ABC-type multidrug transport system, permease component.	ABC-type multidrug transport system, ATPase component.	0.750
GAP42124.1	GAP44080.1	TBC1_11253	TBC1_112241	ABC-type multidrug transport system, permease component.	ABC-type multidrug transport system, ATPase component.	0.793
GAP44075.1	GAP44076.1	TBC1_112236	TBC1_112237	Transcriptional regulator, TetR family.	Outer membrane protein TolC.	0.950
GAP44075.1	GAP44077.1	TBC1_112236	TBC1_112238	Transcriptional regulator, TetR family.	hlyD family secretion protein.	0.930
GAP44075.1	GAP44078.1	TBC1_112236	TBC1_112239	Transcriptional regulator, TetR family.	Uncharacterized protein conserved in bacteria.	0.549
GAP44075.1	GAP44079.1	TBC1_112236	TBC1_112240	Transcriptional regulator, TetR family.	ABC-type multidrug transport system, ATPase component.	0.871
GAP44075.1	GAP44080.1	TBC1_112236	TBC1_112241	Transcriptional regulator, TetR family.	ABC-type multidrug transport system, ATPase component.	0.838
GAP44075.1	GAP44081.1	TBC1_112236	TBC1_112242	Transcriptional regulator, TetR family.	ABC-type multidrug transport system, permease component.	0.834
GAP44075.1	GAP44082.1	TBC1_112236	TBC1_112243	Transcriptional regulator, TetR family.	ABC-type multidrug transport system, permease component.	0.827
GAP44076.1	GAP44075.1	TBC1_112237	TBC1_112236	Outer membrane protein TolC.	Transcriptional regulator, TetR family.	0.950
GAP44076.1	GAP44077.1	TBC1_112237	TBC1_112238	Outer membrane protein TolC.	hlyD family secretion protein.	0.970
GAP44076.1	GAP44078.1	TBC1_112237	TBC1_112239	Outer membrane protein TolC.	Uncharacterized protein conserved in bacteria.	0.549
GAP44076.1	GAP44079.1	TBC1_112237	TBC1_112240	Outer membrane protein TolC.	ABC-type multidrug transport system, ATPase component.	0.899
GAP44076.1	GAP44080.1	TBC1_112237	TBC1_112241	Outer membrane protein TolC.	ABC-type multidrug transport system, ATPase component.	0.895
GAP44076.1	GAP44081.1	TBC1_112237	TBC1_112242	Outer membrane protein TolC.	ABC-type multidrug transport system, permease component.	0.874
GAP44076.1	GAP44082.1	TBC1_112237	TBC1_112243	Outer membrane protein TolC.	ABC-type multidrug transport system, permease component.	0.868
GAP44077.1	GAP42124.1	TBC1_112238	TBC1_11253	hlyD family secretion protein.	ABC-type multidrug transport system, permease component.	0.647
GAP44077.1	GAP44075.1	TBC1_112238	TBC1_112236	hlyD family secretion protein.	Transcriptional regulator, TetR family.	0.930
GAP44077.1	GAP44076.1	TBC1_112238	TBC1_112237	hlyD family secretion protein.	Outer membrane protein TolC.	0.970

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045333

Cellular respiration

6 of 51

1.52

1.91

7.44e-06

GO:0022900

Electron transport chain

7 of 78

1.41

1.8

3.17e-06

GO:0022904

Respiratory electron transport chain

4 of 22

1.71

1.61

0.00030

GO:0009061

Anaerobic respiration

2 of 3

2.28

0.89

0.0233

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008901

Ferredoxin hydrogenase activity

5 of 5

2.45

3.85

3.28e-08

GO:0033748

Hydrogenase (acceptor) activity

4 of 4

2.45

3.13

1.02e-06

GO:0016151

Nickel cation binding

3 of 11

1.89

1.49

0.0010

GO:0046914

Transition metal ion binding

6 of 98

1.24

1.33

4.75e-05

GO:0051538

3 iron, 4 sulfur cluster binding

2 of 6

1.98

0.91

0.0185

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009375

Ferredoxin hydrogenase complex

2 of 2

2.45

1.13

0.0084

GO:0005886

Plasma membrane

7 of 506

0.59

0.37

0.0340

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3524

Mixed, incl. Nitrotoluene degradation, and HupF/HypC family

9 of 10

2.41

7.66

2.24e-17

CL:3522

Ferredoxin hydrogenase activity, and Protein maturation

10 of 18

2.2

7.13

4.07e-18

CL:3534

Nitrotoluene degradation

5 of 5

2.45

4.17

6.54e-09

CL:3525

Mixed, incl. HupF/HypC family, and Alkane catabolic process

4 of 5

2.36

3.04

1.22e-06

CL:3210

Mixed, incl. Two-component system, and Transition metal ion binding

11 of 186

1.23

1.96

8.15e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00633

Nitrotoluene degradation

4 of 4

2.45

3.21

6.98e-07

map02020

Two-component system

6 of 237

0.86

0.64

0.0041

map01120

Microbial metabolism in diverse environments

6 of 308

0.74

0.5

0.0117

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009375

Ferredoxin hydrogenase complex

2 of 2

2.45

0.95

0.0183

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0003

3Fe-4S

2 of 5

2.06

0.71

0.0471

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF14720

NiFe/NiFeSe hydrogenase small subunit C-terminal

2 of 2

2.45

0.8

0.0351

PF00374

Nickel-dependent hydrogenase

2 of 2

2.45

0.8

0.0351

PF01058

NADH ubiquinone oxidoreductase, 20 Kd subunit

2 of 3

2.28

0.79

0.0351

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029014

[NiFe]-hydrogenase, large subunit

3 of 4

2.33

1.51

0.0015

IPR037148

[NiFe]-hydrogenase, small subunit, C-terminal domain superfamily

2 of 2

2.45

0.74

0.0459

IPR037024

[NiFe]-hydrogenase, small subunit, N-terminal domain superfamily

2 of 2

2.45

0.74

0.0459

IPR027394

Cytochrome-c3 hydrogenase, C-terminal

2 of 2

2.45

0.74

0.0459

IPR018194

Nickel-dependent hydrogenase, large subunit, nickel binding site

2 of 2

2.45

0.74

0.0459

(more ...)

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