GAP42132.1 protein (Lentimicrobium saccharophilum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

GAP42132.1

Protease II. (716 aa)

Predicted Functional Partners:

GAP42133.1

0.615

GAP42131.1

0.519

GAP42130.1

0.430

Your Current Organism:

Lentimicrobium saccharophilum

NCBI taxonomy Id: 1678841
Other names: Bacteroidales bacterium TBC1, DSM 100618, JCM 30898, L. saccharophilum, Lentimicrobium saccharophilum Sun et al. 2016, strain TBC1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GAP42130.1	GAP42131.1	TBC1_11259	TBC1_11260	RNA polymerase, sigma 54 subunit, RpoN/SigL.	Uncharacterized conserved protein, DUF169 family.	0.625
GAP42130.1	GAP42132.1	TBC1_11259	TBC1_11261	RNA polymerase, sigma 54 subunit, RpoN/SigL.	Protease II.	0.430
GAP42131.1	GAP42130.1	TBC1_11260	TBC1_11259	Uncharacterized conserved protein, DUF169 family.	RNA polymerase, sigma 54 subunit, RpoN/SigL.	0.625
GAP42131.1	GAP42132.1	TBC1_11260	TBC1_11261	Uncharacterized conserved protein, DUF169 family.	Protease II.	0.519
GAP42131.1	GAP42133.1	TBC1_11260	TBC1_11262	Uncharacterized conserved protein, DUF169 family.	Hypothetical protein.	0.424
GAP42132.1	GAP42130.1	TBC1_11261	TBC1_11259	Protease II.	RNA polymerase, sigma 54 subunit, RpoN/SigL.	0.430
GAP42132.1	GAP42131.1	TBC1_11261	TBC1_11260	Protease II.	Uncharacterized conserved protein, DUF169 family.	0.519
GAP42132.1	GAP42133.1	TBC1_11261	TBC1_11262	Protease II.	Hypothetical protein.	0.615
GAP42133.1	GAP42131.1	TBC1_11262	TBC1_11260	Hypothetical protein.	Uncharacterized conserved protein, DUF169 family.	0.424
GAP42133.1	GAP42132.1	TBC1_11262	TBC1_11261	Hypothetical protein.	Protease II.	0.615

Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.738

expected number of edges:

19

PPI enrichment p-value:

0.0794

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000160

Phosphorelay signal transduction system

2 of 5

2.66

0.75

0.0442

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

2 of 9

2.41

0.73

0.0472

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1766

Mostly uncharacterized, incl. Tubulin/FtsZ-like, C-terminal domain, and Small GTPase Rho

5 of 24

2.38

3.78

3.42e-08

CL:1767

Mostly uncharacterized, incl. Small GTPase Rho, and KN motif and ankyrin repeat domain-containing protein 1-4

4 of 19

2.38

3.21

5.78e-07

CL:1769

Mostly uncharacterized, incl. KN motif and ankyrin repeat domain-containing protein 1-4, and Meprin and TRAF homology

3 of 11

2.5

2.01e-05

CL:1744

Mixed, incl. RHO GTPase cycle, and Actin cytoskeleton

6 of 157

1.64

2.39

5.17e-07

CL:8659

Phosphorelay signal transduction system

2 of 5

2.66

1.55

0.0015

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map05134

Legionellosis

2 of 14

2.22

1.04

0.0114

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

2 of 7

2.52

1.25

0.0052

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR014402

Transcription factor, Skn7-like

2 of 2

3.06

1.08

0.0112

IPR011006

CheY-like superfamily

2 of 5

2.66

0.94

0.0196

IPR001789

Signal transduction response regulator, receiver domain

2 of 5

2.66

0.94

0.0196

IPR027725

Heat shock transcription factor family

2 of 8

2.46

0.92

0.0210

IPR000232

Heat shock factor (HSF)-type, DNA-binding

2 of 8

2.46

0.92

0.0210

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00448

cheY-homologous receiver domain

2 of 4

2.76

1.36

0.0034

SM00415

Heat shock factor

2 of 8

2.46

1.25

0.0051

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