STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PYTT_1078Dnan: dna polymerase iii beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiati [...] (362 aa)    
Predicted Functional Partners:
polA
Pola: dna polymerase i; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 0.999
PYTT_0021
Dna polymerase iii delta subunit.
 
 0.996
PYTT_1210
Hola: dna polymerase iii delta subunit.
 
 
 0.996
dnaX
Dnax nterm: dna polymerase iii subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
 
 
 0.996
PYTT_1859
Polc: dna polymerase iii alpha subunit.
  
 
 0.996
PYTT_1572
Impb/mucb/samb family.
   
 0.994
mutS
Muts1: dna mismatch repair protein muts; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
   
 0.983
PYTT_0519
Exonuclease rnase t/dna polymerase iii.
  
 0.974
PYTT_0001
Trp repressor/replication initiator; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
 
 
 0.949
PYTT_0540
Atpase family associated with various cellular activities (aaa).
  
 0.941
Your Current Organism:
Akkermansia glycaniphila
NCBI taxonomy Id: 1679444
Other names: A. glycaniphila, Akkermansia glycaniphila Ouwerkerk et al. 2016, Akkermansia sp. Pyt, CIP 110913, DSM 100705, strain Pyt
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