| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HgiDIM | metK | RY70_180 | RY70_718 | Cytosine-specific methyltransferase. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.905 |
| MscL | metK | RY70_70 | RY70_718 | Large-conductance mechanosensitive channel protein. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.684 |
| PriA | ilvD | RY70_719 | RY70_716 | Primosomal protein N'. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.455 |
| PriA | metK | RY70_719 | RY70_718 | Primosomal protein N'. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.656 |
| PriA | rpoZ | RY70_719 | RY70_717 | Primosomal protein N'. | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.796 |
| guaA_1 | ilvD | RY70_883 | RY70_716 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.531 |
| guaA_1 | metK | RY70_883 | RY70_718 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.564 |
| guaA_1 | purF | RY70_883 | RY70_1444 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.658 |
| ilvD | PriA | RY70_716 | RY70_719 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Primosomal protein N'. | 0.455 |
| ilvD | guaA_1 | RY70_716 | RY70_883 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.531 |
| ilvD | metK | RY70_716 | RY70_718 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.571 |
| ilvD | rpoZ | RY70_716 | RY70_717 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.649 |
| metE | metF | RY70_988 | RY70_989 | 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.982 |
| metE | metK | RY70_988 | RY70_718 | 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.980 |
| metF | metE | RY70_989 | RY70_988 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.982 |
| metF | metK | RY70_989 | RY70_718 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.584 |
| metK | HgiDIM | RY70_718 | RY70_180 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Cytosine-specific methyltransferase. | 0.905 |
| metK | MscL | RY70_718 | RY70_70 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Large-conductance mechanosensitive channel protein. | 0.684 |
| metK | PriA | RY70_718 | RY70_719 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Primosomal protein N'. | 0.656 |
| metK | guaA_1 | RY70_718 | RY70_883 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.564 |