Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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ligADNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (900 aa)    
Predicted Functional Partners:
RY70_782
TPR repeat-containing protein.
       0.710
leuS
Leucine-tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
 
 0.692
ruvB
Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
  
   
 0.664
ylxH
ATPase; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.
       0.640
RY70_781
Putative PMT family glycosyl transferase.
       0.618
TruA
tRNA pseudouridine synthase A.
     
 0.574
cmk
Bifunctional cytidylate kinase/GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the cytidylate kinase family. Type 1 subfamily.
  
  
 0.560
dnaG
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
 
   
 0.548
PolA
DNA polymerase I.
 
   
 0.542
pheT
Phenylalanine-tRNA ligase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
  
  
 0.533
Your Current Organism:
Bifidobacterium bifidum
NCBI taxonomy Id: 1681
Other names: AS 1.2212, ATCC 29521, Actinobacterium bifidum, Actinomyces bifidus, Actinomyces parabifidus, B. bifidum, BCRC 14615, Bacillus bifidus, Bacillus bifidus communis, Bacterium bifidum, Bacteroides bifidus, Bifidibacterium bifidum, CCRC 14615, CCRC:14615, CCUG 18364, CCUG 45217, CIP 56.7, Cohnistreptothrix bifidus, DSM 20456, IFO 14252, KCTC 3202, LMG 11041, LMG 8810, LMG:11041, LMG:8810, Lactobacillus bifidus type II, Lactobacillus parabifidus, NBRC 100015, NBRC 14252, NCFB 2715, NCIMB 702715, NCTC 13001, Nocardia bifida, Tissieria bifida, strain Ti
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