A0A316UD06 protein (Pseudomicrostroma glucosiphilum)

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

A0A316UD06

Uncharacterized protein. (873 aa)

Predicted Functional Partners:

A0A316UDP5

0.928

A0A316UAC5

0.759

A0A316UB56

0.758

A0A316UCX1

0.758

A0A316U0G1

0.757

A0A316UCV9

0.757

A0A316UFA5

0.757

A0A316UHZ2

0.757

A0A316U525

0.756

A0A316UBJ0

0.756

Your Current Organism:

Pseudomicrostroma glucosiphilum

NCBI taxonomy Id: 1684307
Other names: CBS 14053, MCA 4718, Microstromatales sp. MCA4718, NRRL 66310, P. glucosiphilum, Rhodotorula sp. MCA 4718

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A316U0G1	A0A316UB56	Uncharacterized protein.	TPR-like protein.	0.998
A0A316U0G1	A0A316UBJ0	Uncharacterized protein.	RING/U-box.	0.999
A0A316U0G1	A0A316UCV9	Uncharacterized protein.	ANAPC5 domain-containing protein.	0.998
A0A316U0G1	A0A316UD06	Uncharacterized protein.	Uncharacterized protein.	0.757
A0A316U0G1	A0A316UFA5	Uncharacterized protein.	Anaphase-promoting complex, subunit 10.	0.999
A0A316U0G1	A0A316UHZ2	Uncharacterized protein.	ANAPC4 domain-containing protein.	0.997
A0A316U525	A0A316UAC5	Uncharacterized protein.	CDC73-domain-containing protein.	0.998
A0A316U525	A0A316UCX1	Uncharacterized protein.	Leo1-domain-containing protein.	0.998
A0A316U525	A0A316UD06	Uncharacterized protein.	Uncharacterized protein.	0.756
A0A316UAC5	A0A316U525	CDC73-domain-containing protein.	Uncharacterized protein.	0.998
A0A316UAC5	A0A316UCX1	CDC73-domain-containing protein.	Leo1-domain-containing protein.	0.998
A0A316UAC5	A0A316UD06	CDC73-domain-containing protein.	Uncharacterized protein.	0.759
A0A316UB56	A0A316U0G1	TPR-like protein.	Uncharacterized protein.	0.998
A0A316UB56	A0A316UBJ0	TPR-like protein.	RING/U-box.	0.998
A0A316UB56	A0A316UCV9	TPR-like protein.	ANAPC5 domain-containing protein.	0.997
A0A316UB56	A0A316UD06	TPR-like protein.	Uncharacterized protein.	0.758
A0A316UB56	A0A316UFA5	TPR-like protein.	Anaphase-promoting complex, subunit 10.	0.998
A0A316UB56	A0A316UHZ2	TPR-like protein.	ANAPC4 domain-containing protein.	0.997
A0A316UBJ0	A0A316U0G1	RING/U-box.	Uncharacterized protein.	0.999
A0A316UBJ0	A0A316UB56	RING/U-box.	TPR-like protein.	0.998

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

49

average node degree:

8.91

avg. local clustering coefficient:

0.91

expected number of edges:

12

PPI enrichment p-value:

3.33e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009082

Branched-chain amino acid biosynthetic process

4 of 16

2.28

2.56

1.04e-05

GO:0009098

Leucine biosynthetic process

3 of 6

2.58

2.42

3.13e-05

GO:0009097

Isoleucine biosynthetic process

3 of 12

2.28

2.07

0.00011

GO:1901605

Alpha-amino acid metabolic process

5 of 123

1.49

1.63

5.61e-05

GO:0019752

Carboxylic acid metabolic process

7 of 281

1.27

1.49

1.04e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046912

Acyltransferase activity, acyl groups converted into alkyl on transfer

3 of 4

2.75

2.36

4.63e-05

GO:0003852

2-isopropylmalate synthase activity

2 of 2

2.88

1.45

0.0024

GO:0016746

Acyltransferase activity

4 of 80

1.58

1.3

0.0012

GO:0019842

Vitamin binding

3 of 51

1.65

1.06

0.0063

GO:0016903

Oxidoreductase activity, acting on the aldehyde or oxo group of donors

2 of 18

1.92

0.75

0.0383

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

7 of 319

1.22

1.43

6.56e-06

GO:0005737

Cytoplasm

8 of 1478

0.61

0.43

0.0086

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:731

Valine, leucine and isoleucine biosynthesis

6 of 17

2.43

5.02

7.80e-11

CL:635

Mixed, incl. Citrate cycle (TCA cycle), and Valine, leucine and isoleucine biosynthesis

8 of 65

1.97

4.49

5.96e-12

CL:755

Aminotransferase class IV, and 2-isopropylmalate synthase activity

4 of 5

2.78

3.9

5.36e-08

CL:1391

Phosphopantetheine, and Cytochrome P450 superfamily

3 of 24

1.97

1.5

0.0011

CL:1400

Phosphopantetheine attachment site

2 of 5

2.48

1.27

0.0047

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00290

Valine, leucine and isoleucine biosynthesis

5 of 16

2.37

4.21

3.68e-09

map01210

2-Oxocarboxylic acid metabolism

4 of 28

2.03

2.6

3.82e-06

map00620

Pyruvate metabolism

4 of 50

1.78

2.12

1.66e-05

map00280

Valine, leucine and isoleucine degradation

2 of 15

2.0

1.24

0.0040

map00770

Pantothenate and CoA biosynthesis

2 of 19

1.9

1.16

0.0054

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005739

Mitochondrion

3 of 48

1.67

0.97

0.0104

GOCC:0005737

Cytoplasm

7 of 1152

0.66

0.43

0.0200

GOCC:0005622

Intracellular

9 of 1930

0.55

0.39

0.0105

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0100

Branched-chain amino acid biosynthesis

4 of 11

2.44

3.27

5.08e-07

KW-0596

Phosphopantetheine

3 of 19

2.08

1.87

0.00020

KW-0032

Aminotransferase

2 of 25

1.78

0.78

0.0309

KW-0012

Acyltransferase

2 of 29

1.72

0.76

0.0327

KW-0004

4Fe-4S

2 of 39

1.59

0.68

0.0442

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00682

HMGL-like

3 of 3

2.88

2.5

2.66e-05

PF14765

Polyketide synthase dehydratase

2 of 2

2.88

1.34

0.0037

PF00550

Phosphopantetheine attachment site

2 of 14

2.03

0.7

0.0487

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002034

Alpha-isopropylmalate/homocitrate synthase, conserved site

3 of 3

2.88

2.29

6.52e-05

IPR000891

Pyruvate carboxyltransferase

3 of 3

2.88

2.29

6.52e-05

IPR036736

ACP-like superfamily

3 of 19

2.08

1.44

0.0017

IPR009081

Phosphopantetheine binding ACP domain

3 of 19

2.08

1.44

0.0017

IPR036230

2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain superfamily

2 of 2

2.88

1.35

0.0036

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00917

LeuA allosteric (dimerisation) domain

2 of 2

2.88

1.57

0.0014

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