node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RY69_1618 | lepB | RY69_1618 | RY69_1620 | Transcriptional regulator, LacI family. | Putative signal peptidase I; Belongs to the peptidase S26 family. | 0.651 |
RY69_1618 | rnhB | RY69_1618 | RY69_1619 | Transcriptional regulator, LacI family. | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.663 |
RY69_1618 | rplS | RY69_1618 | RY69_1621 | Transcriptional regulator, LacI family. | 50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.432 |
RY69_1911 | lepB | RY69_1911 | RY69_1620 | GrpE. | Putative signal peptidase I; Belongs to the peptidase S26 family. | 0.426 |
RY69_1911 | rnhB | RY69_1911 | RY69_1619 | GrpE. | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.543 |
RY69_1911 | rplS | RY69_1911 | RY69_1621 | GrpE. | 50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.688 |
dnaJ | rnhB | RY69_950 | RY69_1619 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.543 |
dnaJ | rplS | RY69_950 | RY69_1621 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.688 |
dnaN | recQ | RY69_2057 | RY69_1485 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | ATP-dependent DNA helicase RecQ. | 0.653 |
dnaN | rnhB | RY69_2057 | RY69_1619 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.875 |
dnaN | thyA | RY69_2057 | RY69_224 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.762 |
lepB | RY69_1618 | RY69_1620 | RY69_1618 | Putative signal peptidase I; Belongs to the peptidase S26 family. | Transcriptional regulator, LacI family. | 0.651 |
lepB | RY69_1911 | RY69_1620 | RY69_1911 | Putative signal peptidase I; Belongs to the peptidase S26 family. | GrpE. | 0.426 |
lepB | rnhB | RY69_1620 | RY69_1619 | Putative signal peptidase I; Belongs to the peptidase S26 family. | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.848 |
lepB | rplS | RY69_1620 | RY69_1621 | Putative signal peptidase I; Belongs to the peptidase S26 family. | 50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.670 |
recQ | dnaN | RY69_1485 | RY69_2057 | ATP-dependent DNA helicase RecQ. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.653 |
recQ | rnhA | RY69_1485 | RY69_181 | ATP-dependent DNA helicase RecQ. | Ribonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.455 |
recQ | rnhB | RY69_1485 | RY69_1619 | ATP-dependent DNA helicase RecQ. | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.657 |
rnhA | recQ | RY69_181 | RY69_1485 | Ribonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | ATP-dependent DNA helicase RecQ. | 0.455 |
rnhA | rnhB | RY69_181 | RY69_1619 | Ribonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.726 |