| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| RY69_1949 | htpX | RY69_1949 | RY69_1951 | EamA-like transporter family protein. | Protease HtpX-like protein; Belongs to the peptidase M48B family. | 0.430 |
| RY69_1952 | htpX | RY69_1952 | RY69_1951 | Putative NADPH-ferredoxin reductase FprA. | Protease HtpX-like protein; Belongs to the peptidase M48B family. | 0.508 |
| RY69_1954 | dnaK | RY69_1954 | RY69_1913 | Peptidase S1 and S6, chymotrypsin/Hap. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.528 |
| RY69_1954 | grpE | RY69_1954 | RY69_1912 | Peptidase S1 and S6, chymotrypsin/Hap. | Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.422 |
| RY69_1954 | htpX | RY69_1954 | RY69_1951 | Peptidase S1 and S6, chymotrypsin/Hap. | Protease HtpX-like protein; Belongs to the peptidase M48B family. | 0.428 |
| RY69_668 | dnaK | RY69_668 | RY69_1913 | Transposase, mutator-like family protein. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.613 |
| RY69_668 | htpX | RY69_668 | RY69_1951 | Transposase, mutator-like family protein. | Protease HtpX-like protein; Belongs to the peptidase M48B family. | 0.609 |
| aspS | htpX | RY69_458 | RY69_1951 | Aspartate-tRNA ligase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. | Protease HtpX-like protein; Belongs to the peptidase M48B family. | 0.417 |
| dnaK | RY69_1954 | RY69_1913 | RY69_1954 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Peptidase S1 and S6, chymotrypsin/Hap. | 0.528 |
| dnaK | RY69_668 | RY69_1913 | RY69_668 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Transposase, mutator-like family protein. | 0.613 |
| dnaK | grpE | RY69_1913 | RY69_1912 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.999 |
| dnaK | hflB | RY69_1913 | RY69_317 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | ATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.683 |
| dnaK | htpX | RY69_1913 | RY69_1951 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Protease HtpX-like protein; Belongs to the peptidase M48B family. | 0.463 |
| dnaK | msrB | RY69_1913 | RY69_1965 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Methionine-R-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.564 |
| dnaK | secY | RY69_1913 | RY69_158 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Protein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.678 |
| grpE | RY69_1954 | RY69_1912 | RY69_1954 | Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | Peptidase S1 and S6, chymotrypsin/Hap. | 0.422 |
| grpE | dnaK | RY69_1912 | RY69_1913 | Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.999 |
| grpE | hflB | RY69_1912 | RY69_317 | Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | ATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.416 |
| grpE | htpX | RY69_1912 | RY69_1951 | Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | Protease HtpX-like protein; Belongs to the peptidase M48B family. | 0.574 |
| grpE | msrB | RY69_1912 | RY69_1965 | Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | Methionine-R-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.726 |
