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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BCOR_0715Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (478 aa)    
Predicted Functional Partners:
pyrD
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate.
 
 0.999
pyrB
Aspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 0.999
BCOR_0713
Dihydroorotate dehydrogenase electron transfer subunit.
 
 
 0.997
carA
Carbamoyl-phosphate synthase small chain; Belongs to the CarA family.
  
 0.994
carB
Carbamoyl phosphate synthase large subunit; Belongs to the CarB family.
 
 0.990
BCOR_0716
Aspartate carbamoyltransferase PyrI.
    
 0.983
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
  
 0.977
pyrF
Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily.
 
  
 0.977
BCOR_0718
Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]
       0.714
BCOR_0700
Shikimate 5-dehydrogenase.
     
 0.683
Your Current Organism:
Bifidobacterium coryneforme
NCBI taxonomy Id: 1687
Other names: AS 1.2279, ATCC 25911, B. coryneforme, BCRC 14675, Bifidobacterium sp. Bma6, CCRC 14675, CCRC:14675, CCUG 34986, DSM 20216, JCM 5819, LMG 18911, LMG:18911
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