Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (406 aa)    
Predicted Functional Partners:
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 0.959
BCOR_0838
O-acetylhomoserine aminocarboxypropyltransferase.
   
 
 0.914
BCOR_1192
O-acetylhomoserine aminocarboxypropyltransferase.
   
 
 0.914
BCOR_1176
Aldehyde-alcohol dehydrogenase 2; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
   
 
 0.800
trpB
Indole-3-glycerol phosphate synthase; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine; Belongs to the TrpC family.
   
   0.779
mscL
Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
   
    0.754
BCOR_1129
S-adenosylhomocysteine hydrolase.
 
 
 0.744
groL
GroEL 60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
   
 
 0.739
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
  
 0.708
rpoZ
DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
  
    0.686
Your Current Organism:
Bifidobacterium coryneforme
NCBI taxonomy Id: 1687
Other names: AS 1.2279, ATCC 25911, B. coryneforme, BCRC 14675, Bifidobacterium sp. Bma6, CCRC 14675, CCRC:14675, CCUG 34986, DSM 20216, JCM 5819, LMG 18911, LMG:18911
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