STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
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[Homology]
Score
BCOR_1007Phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. Belongs to the PurK/PurT family. (430 aa)    
Predicted Functional Partners:
BCOR_1009
Phosphoribosylformylglycinamidine synthase.
  
 
 0.999
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase.
   
 
 0.968
purD
Phosphoribosylamine-glycine ligase; Belongs to the GARS family.
  
 
 0.964
purE
Phosphoribosylaminoimidazole carboxylase carboxyltransferase subunit PurE; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
 0.961
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
  0.905
folD
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
     
 0.903
BCOR_1203
5-formyltetrahydrofolate cyclo-ligase.
    
  0.901
fmt
methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
     
  0.900
BCOR_1090
Dihydrofolate reductase; Belongs to the dihydrofolate reductase family.
     
  0.900
BCOR_1310
Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.
     
  0.900
Your Current Organism:
Bifidobacterium coryneforme
NCBI taxonomy Id: 1687
Other names: AS 1.2279, ATCC 25911, B. coryneforme, BCRC 14675, Bifidobacterium sp. Bma6, CCRC 14675, CCRC:14675, CCUG 34986, DSM 20216, JCM 5819, LMG 18911, LMG:18911
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