STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BCUN_0077Folylpolyglutamate synthase. (512 aa)    
Predicted Functional Partners:
BCUN_1094
Dihydrofolate reductase; Belongs to the dihydrofolate reductase family.
     
 0.975
BCUN_1654
Dihydroneopterin aldolase.
  
 
 0.963
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
     
 0.959
BCUN_1165
Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.
 
 
 0.712
trpC
Bifunctional tryptophan synthase subunit beta/indole-3-glycerol phosphate synthase; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine; Belongs to the TrpC family.
     
 0.590
valS
valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner.
  
  
 0.551
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
 
  
 0.545
BCUN_0701
Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
  
 
 0.544
BCUN_0068
Nudix hydrolase family protein.
    
 0.532
BCUN_0076
Response regulator.
       0.511
Your Current Organism:
Bifidobacterium cuniculi
NCBI taxonomy Id: 1688
Other names: AS 1.2239, ATCC 27916, B. cuniculi, BCRC 14672, CCRC 14672, CCRC:14672, CCUG 24610, CIP 103379, DSM 20435, LMG 10738, LMG:10738, strain RA93
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