Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
BCUN_0752Isocitrate dehydrogenase, NADP-dependent; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (407 aa)    
Predicted Functional Partners:
BCUN_0119
Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 0.984
BCUN_2205
Citrate synthase 1; Belongs to the citrate synthase family.
  
 0.939
BCUN_0462
Glutamate synthase.
    
 0.932
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
  
 0.927
BCUN_1447
Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.901
BCUN_1357
Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
   
 0.887
sucC
succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.877
BCUN_1309
Adenylosuccinate lyase.
  
 
 0.874
ldh
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
  
 0.871
BCUN_1202
L-lactate dehydrogenase 1; Belongs to the LDH/MDH superfamily.
  
 0.871
Your Current Organism:
Bifidobacterium cuniculi
NCBI taxonomy Id: 1688
Other names: AS 1.2239, ATCC 27916, B. cuniculi, BCRC 14672, CCRC 14672, CCRC:14672, CCUG 24610, CIP 103379, DSM 20435, LMG 10738, LMG:10738, strain RA93
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