node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCUN_0952 | BCUN_0954 | BCUN_0952 | BCUN_0954 | Cation transporter. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.686 |
BCUN_0952 | BCUN_0955 | BCUN_0952 | BCUN_0955 | Cation transporter. | Hydrolyase. | 0.686 |
BCUN_0952 | nadK | BCUN_0952 | BCUN_0953 | Cation transporter. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.700 |
BCUN_0954 | BCUN_0952 | BCUN_0954 | BCUN_0952 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Cation transporter. | 0.686 |
BCUN_0954 | BCUN_0955 | BCUN_0954 | BCUN_0955 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Hydrolyase. | 0.853 |
BCUN_0954 | lexA | BCUN_0954 | BCUN_0043 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.658 |
BCUN_0954 | nadK | BCUN_0954 | BCUN_0953 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.902 |
BCUN_0954 | radA | BCUN_0954 | BCUN_1546 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | radA DNA repair protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | 0.717 |
BCUN_0954 | recA | BCUN_0954 | BCUN_0140 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.861 |
BCUN_0954 | recF | BCUN_0954 | BCUN_1440 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Recombination protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | 0.671 |
BCUN_0954 | ruvA | BCUN_0954 | BCUN_0807 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Crossover junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.689 |
BCUN_0954 | ruvB | BCUN_0954 | BCUN_0806 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Crossover junction ATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.644 |
BCUN_0954 | uvrB | BCUN_0954 | BCUN_0322 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.650 |
BCUN_0955 | BCUN_0952 | BCUN_0955 | BCUN_0952 | Hydrolyase. | Cation transporter. | 0.686 |
BCUN_0955 | BCUN_0954 | BCUN_0955 | BCUN_0954 | Hydrolyase. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.853 |
BCUN_0955 | nadK | BCUN_0955 | BCUN_0953 | Hydrolyase. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.830 |
lexA | BCUN_0954 | BCUN_0043 | BCUN_0954 | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.658 |
lexA | recA | BCUN_0043 | BCUN_0140 | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.992 |
lexA | recF | BCUN_0043 | BCUN_1440 | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Recombination protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | 0.479 |
lexA | ruvA | BCUN_0043 | BCUN_0807 | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Crossover junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.665 |