STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
htpXHeat shock protein. Metallo peptidase. MEROPS family M48B; Belongs to the peptidase M48B family. (285 aa)    
Predicted Functional Partners:
TrxA
Thioredoxin.
  
  
 0.632
grpE
Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...]
  
  
 0.591
SEH39799.1
Multi-sensor signal transduction histidine kinase.
 
     0.590
SEI04838.1
Modulator of FtsH protease; Belongs to the BI1 family.
  
  
 0.569
SEH39750.1
Resistance to homoserine/threonine (RhtB) family protein.
  
    0.540
SEH39774.1
16S rRNA (cytosine967-C5)-methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
       0.535
SEH39786.1
Protein of unknown function.
       0.535
ftsH
Membrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
  
 
 0.524
SEI26122.1
Cell division protease FtsH; Belongs to the AAA ATPase family.
  
 
 0.523
dnaJ
Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...]
  
 
 0.518
Your Current Organism:
Paraburkholderia hospita
NCBI taxonomy Id: 169430
Other names: Burkholderia hospita, Burkholderia hospita Goris et al. 2003, Burkholderia sp. LMG 20598, CCUG 43658, CCUG 43661, CIP 107793, DSM 17164, LMG 20598, LMG:20598, P. hospita, Paraburkholderia hospita (Goris et al. 2003) Sawana et al. 2015, strain Goris R-8366, strain R-8366
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