Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mccBCystathionine gamma-lyase. (382 aa)    
Predicted Functional Partners:
yitJ
Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase.
 
 0.993
cysK1
O-acetylserine sulfhydrylase; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
 0.977
cysK
Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
 0.977
metH
Methionine synthase.
  
 
 0.972
metA
Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.
  
 
 0.961
metC
Cystathionine beta-lyase.
 
  
 
0.949
luxS
S-ribosylhomocysteine lyase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
  
 
 0.948
sir_3
Sulfite reductase; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
  
 
 0.946
mdeA_1
Methionine gamma-lyase.
 
 
0.938
mdeA_2
Methionine gamma-lyase.
 
 
0.935
Your Current Organism:
Clostridium saccharobutylicum
NCBI taxonomy Id: 169679
Other names: ATCC BAA-117, C. saccharobutylicum, Clostridium saccharobutylicum Keis et al. 2001, DSM 13864, strain NCP 262
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