STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dnaJ_1Chaperone protein DnaJ. (146 aa)    
Predicted Functional Partners:
dnaK_1
Chaperone protein DnaK; Belongs to the heat shock protein 70 family.
 
 0.963
dnaK_2
Chaperone protein DnaK; Belongs to the heat shock protein 70 family.
 
 0.963
dnaK_3
Chaperone protein DnaK.
 
 0.963
dnaK_4
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 0.963
grpE
Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
 
 
 0.938
stp_1
Serine/threonine phosphatase stp.
  
   0.905
AQR99001.1
Hypothetical protein.
  
 0.873
AQR98998.1
Hypothetical protein.
 
   0.871
htpG_3
Chaperone protein HtpG.
  
 0.856
nifJ_1
Pyruvate-flavodoxin oxidoreductase.
   
 
 0.852
Your Current Organism:
Clostridium saccharobutylicum
NCBI taxonomy Id: 169679
Other names: ATCC BAA-117, C. saccharobutylicum, Clostridium saccharobutylicum Keis et al. 2001, DSM 13864, strain NCP 262
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.