STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdeA_2Methionine gamma-lyase. (429 aa)    
Predicted Functional Partners:
metA
Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.
 
 
 0.971
yitJ
Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase.
  
 
 0.948
metH
Methionine synthase.
  
 
 0.947
metC
Cystathionine beta-lyase.
 
 
0.938
mccB
Cystathionine gamma-lyase.
 
 
0.935
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase.
  
 
 0.924
mmuM
Homocysteine S-methyltransferase.
     
 0.917
luxS
S-ribosylhomocysteine lyase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
     
 0.907
mdeA_1
Methionine gamma-lyase.
  
  
 
0.905
hom
Homoserine dehydrogenase.
  
 
 0.871
Your Current Organism:
Clostridium saccharobutylicum
NCBI taxonomy Id: 169679
Other names: ATCC BAA-117, C. saccharobutylicum, Clostridium saccharobutylicum Keis et al. 2001, DSM 13864, strain NCP 262
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