| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AQR99718.1 | glyA | CSACC_15270 | CSACC_27930 | Glycine/sarcosine N-methyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.925 |
| AQR99718.1 | ltaE | CSACC_15270 | CSACC_38570 | Glycine/sarcosine N-methyltransferase. | Low specificity L-threonine aldolase. | 0.900 |
| AQS02025.1 | ltaE | CSACC_38580 | CSACC_38570 | Insulinase. | Low specificity L-threonine aldolase. | 0.567 |
| AQS02056.1 | guaB | CSACC_38890 | CSACC_03620 | Cobalt-dependent inorganic pyrophosphatase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.790 |
| AQS02056.1 | ltaE | CSACC_38890 | CSACC_38570 | Cobalt-dependent inorganic pyrophosphatase. | Low specificity L-threonine aldolase. | 0.499 |
| AQS02056.1 | thrC | CSACC_38890 | CSACC_31400 | Cobalt-dependent inorganic pyrophosphatase. | Threonine synthase. | 0.400 |
| cinA_2 | glyA | CSACC_43160 | CSACC_27930 | Putative competence-damage inducible protein; Belongs to the CinA family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.448 |
| cinA_2 | guaB | CSACC_43160 | CSACC_03620 | Putative competence-damage inducible protein; Belongs to the CinA family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.484 |
| cinA_2 | ltaE | CSACC_43160 | CSACC_38570 | Putative competence-damage inducible protein; Belongs to the CinA family. | Low specificity L-threonine aldolase. | 0.442 |
| cinA_2 | ribD | CSACC_43160 | CSACC_14580 | Putative competence-damage inducible protein; Belongs to the CinA family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.461 |
| cinA_2 | thrC | CSACC_43160 | CSACC_31400 | Putative competence-damage inducible protein; Belongs to the CinA family. | Threonine synthase. | 0.418 |
| glyA | AQR99718.1 | CSACC_27930 | CSACC_15270 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Glycine/sarcosine N-methyltransferase. | 0.925 |
| glyA | cinA_2 | CSACC_27930 | CSACC_43160 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative competence-damage inducible protein; Belongs to the CinA family. | 0.448 |
| glyA | guaB | CSACC_27930 | CSACC_03620 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.775 |
| glyA | ltaE | CSACC_27930 | CSACC_38570 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Low specificity L-threonine aldolase. | 0.942 |
| glyA | ribD | CSACC_27930 | CSACC_14580 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.448 |
| glyA | tdcB | CSACC_27930 | CSACC_28170 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-threonine dehydratase catabolic TdcB. | 0.926 |
| guaB | AQS02056.1 | CSACC_03620 | CSACC_38890 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Cobalt-dependent inorganic pyrophosphatase. | 0.790 |
| guaB | cinA_2 | CSACC_03620 | CSACC_43160 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Putative competence-damage inducible protein; Belongs to the CinA family. | 0.484 |
| guaB | glyA | CSACC_03620 | CSACC_27930 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.775 |