STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pfpPyrophosphate--fructose 6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (405 aa)    
Predicted Functional Partners:
pgi
Glucose-6-phosphate isomerase; Belongs to the GPI family.
  
 0.986
pyk_1
Pyruvate kinase; Belongs to the pyruvate kinase family.
 
 
 0.971
pyk_2
Pyruvate kinase; Belongs to the pyruvate kinase family.
 
 
 0.971
iolJ
6-phospho-5-dehydro-2-deoxy-D-gluconate aldolase.
  
 
 0.939
fba
Fructose-bisphosphate aldolase.
  
 
 0.939
gatY
D-tagatose-1,6-bisphosphate aldolase subunit GatY.
  
 
 0.939
lacB
Galactose-6-phosphate isomerase subunit LacB.
  
 
 0.934
lacA_3
Galactose-6-phosphate isomerase subunit LacA.
  
 
 0.933
pfkA1
6-phosphofructokinase 1; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
  
  
0.927
manA_1
Mannose-6-phosphate isomerase ManA.
 
  
 0.923
Your Current Organism:
Clostridium saccharobutylicum
NCBI taxonomy Id: 169679
Other names: ATCC BAA-117, C. saccharobutylicum, Clostridium saccharobutylicum Keis et al. 2001, DSM 13864, strain NCP 262
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