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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
menD2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylic-acid synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily. (542 aa)    
Predicted Functional Partners:
AQS73882.1
Isochorismate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.974
AQS72894.1
1,4-dihydroxy-2-naphthoyl-CoA synthase; Catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family.
 
  
 0.972
menC
O-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
 
   
 0.932
menG
Bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
     
 0.930
menA
1,4-dihydroxy-2-naphthoate polyprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily.
 
   
 0.848
AQS72904.1
DUF3592 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.845
AQS72885.1
O-succinylbenzoic acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.835
AQS72902.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.689
AQS72899.1
Macrolide ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.670
AQS72900.1
ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.670
Your Current Organism:
Corynebacterium ammoniagenes
NCBI taxonomy Id: 1697
Other names: ATCC 6871, Bacterium ammoniagenes, Brevibacterium ammoniagenes, Brevibacterium sp. NCIM 2268, C. ammoniagenes, CCUG 38796, CIP 101283, Corynebacterium ammoniigenes, DSM 20306, IFO 12612, NBRC 12612, NCCB 60030, NCIB 8143, NCIB:8143, NCIMB 8143, VKM B-672
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