STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AKX45514.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (387 aa)    
Predicted Functional Partners:
AKX45515.1
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 0.999
AKX45513.1
Heme biosynthesis protein HemY; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.974
AKX45252.1
Sirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
     
 0.909
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
     
 0.904
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
  
 0.845
dsbB
Disulfide bond formation protein DsbB; Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein; Belongs to the DsbB family.
 
     0.704
lolB
Hypothetical protein; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
  
     0.650
AKX45652.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.640
AKX45696.1
GTP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.589
lptE
Hypothetical protein; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane; Belongs to the LptE lipoprotein family.
  
     0.552
Your Current Organism:
Oblitimonas alkaliphila
NCBI taxonomy Id: 1697053
Other names: CCUG 67636, DSM 100830, O. alkaliphila, Oblitimonas alkaliphila Drobish et al. 2016, Pseudomonadaceae bacterium B4199, Pseudomonadaceae bacterium C6819, Pseudomonadaceae bacterium C6918, Pseudomonadaceae bacterium D2441, Pseudomonadaceae bacterium D3318, Pseudomonadaceae bacterium E1086, Pseudomonadaceae bacterium E1148, Pseudomonadaceae bacterium E5571, bacterium B4199, bacterium C6819, bacterium C6918, bacterium D2441, bacterium D3318, bacterium E1086, bacterium E1148, bacterium E5571, strain B4199
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