STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rsbWsigma-B activity negative regulator RsbW; Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B). (157 aa)    
Predicted Functional Partners:
rsbV
Anti-anti-sigma factor (antagonist of RsbW); Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity); Belongs to the anti-sigma-factor antagonist family.
 
 0.999
sigB
RNA polymerase sigma-37 factor (sigma-B); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
 0.999
rsbU
RsbU protein; Highly similar to serine phosphatase RsbU.
 
 0.992
rsbX
Indirect negative regulation of sigma B dependant gene expression (serine phosphatase).
 
 0.992
rsbS
RsbS protein; Highly similar to negative regulation of sigma-B activity.
 
 0.979
RsbR
RsbR protein; Highly similar to positive regulator of sigma-B activity.
 
 0.974
lmo0799
Blue-light photoreceptor; Exhibits the same spectroscopical features and blue-light induced photochemistry as plants phototropins, with the reversible formation of a blue-shifted photoproduct, assigned to an FMN-cysteine thiol adduct. Positive regulator in the activation of the general stress transcription factor sigma-B (By similarity).
  
 0.961
lmo0161
Lmo0161 protein.
 
 0.931
lmo1642
Lmo1642 protein; Similar to putative sigma factor regulator.
 
 0.924
lmo1842
Similar to unknown proteins.
  
 0.914
Your Current Organism:
Listeria monocytogenes
NCBI taxonomy Id: 169963
Other names: L. monocytogenes EGD-e, Listeria monocytogenes ATCC BAA-679, Listeria monocytogenes EGD-e, Listeria monocytogenes EGDe, Listeria monocytogenes str. EGD-e, Listeria monocytogenes strain EGD-e
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