node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
birA | guaB | gene:17594589 | gene:17595475 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.700 |
birA | lmo1562 | gene:17594589 | gene:17594219 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Transcriptional repressor NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.505 |
cmk | guaB | gene:17594624 | gene:17595475 | Similar to cytidylate kinase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.574 |
cmk | lmo1562 | gene:17594624 | gene:17594219 | Similar to cytidylate kinase. | Transcriptional repressor NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.712 |
cmk | polA | gene:17594624 | gene:17594222 | Similar to cytidylate kinase. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.448 |
cmk | thrS | gene:17594624 | gene:17594216 | Similar to cytidylate kinase. | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). | 0.476 |
dnaB | dnaI | gene:17594218 | gene:17594217 | Chromosome replication initiation / membrane attachment protein DnaB. | Primosome component (helicase loader) DnaI. | 0.980 |
dnaB | lmo1562 | gene:17594218 | gene:17594219 | Chromosome replication initiation / membrane attachment protein DnaB. | Transcriptional repressor NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.902 |
dnaB | lmo1563 | gene:17594218 | gene:17594220 | Chromosome replication initiation / membrane attachment protein DnaB. | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.634 |
dnaB | mutM | gene:17594218 | gene:17594221 | Chromosome replication initiation / membrane attachment protein DnaB. | Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.718 |
dnaB | polA | gene:17594218 | gene:17594222 | Chromosome replication initiation / membrane attachment protein DnaB. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.660 |
dnaB | thrS | gene:17594218 | gene:17594216 | Chromosome replication initiation / membrane attachment protein DnaB. | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). | 0.470 |
dnaI | dnaB | gene:17594217 | gene:17594218 | Primosome component (helicase loader) DnaI. | Chromosome replication initiation / membrane attachment protein DnaB. | 0.980 |
dnaI | lmo1562 | gene:17594217 | gene:17594219 | Primosome component (helicase loader) DnaI. | Transcriptional repressor NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.805 |
dnaI | lmo1563 | gene:17594217 | gene:17594220 | Primosome component (helicase loader) DnaI. | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.720 |
dnaI | mutM | gene:17594217 | gene:17594221 | Primosome component (helicase loader) DnaI. | Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.826 |
dnaI | polA | gene:17594217 | gene:17594222 | Primosome component (helicase loader) DnaI. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.772 |
dnaI | thrS | gene:17594217 | gene:17594216 | Primosome component (helicase loader) DnaI. | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). | 0.470 |
guaB | birA | gene:17595475 | gene:17594589 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.700 |
guaB | cmk | gene:17595475 | gene:17594624 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Similar to cytidylate kinase. | 0.574 |