node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PdhD | glyA | gene:17593711 | gene:17595250 | Highly similar to dihydrolipoamide dehydrogenase, E3 subunit of pyruvate dehydrogenase complex. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.905 |
PdhD | lmo0764 | gene:17593711 | gene:17593415 | Highly similar to dihydrolipoamide dehydrogenase, E3 subunit of pyruvate dehydrogenase complex. | Similar to lipoate-protein ligase. | 0.833 |
PdhD | lmo0931 | gene:17593711 | gene:17593586 | Highly similar to dihydrolipoamide dehydrogenase, E3 subunit of pyruvate dehydrogenase complex. | Similar to lipoate protein ligase A. | 0.835 |
PdhD | lmo1348 | gene:17593711 | gene:17594005 | Highly similar to dihydrolipoamide dehydrogenase, E3 subunit of pyruvate dehydrogenase complex. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.959 |
PdhD | lmo1349 | gene:17593711 | gene:17594006 | Highly similar to dihydrolipoamide dehydrogenase, E3 subunit of pyruvate dehydrogenase complex. | Probable glycine dehydrogenase (decarboxylating) subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.950 |
PdhD | lmo1350 | gene:17593711 | gene:17594007 | Highly similar to dihydrolipoamide dehydrogenase, E3 subunit of pyruvate dehydrogenase complex. | Probable glycine dehydrogenase (decarboxylating) subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.950 |
PdhD | lmo1371 | gene:17593711 | gene:17594028 | Highly similar to dihydrolipoamide dehydrogenase, E3 subunit of pyruvate dehydrogenase complex. | Dihydrolipoyl dehydrogenase; Similar to branched-chain alpha-keto acid dehydrogenase E3 subunit. | 0.951 |
PdhD | lmo1734 | gene:17593711 | gene:17594416 | Highly similar to dihydrolipoamide dehydrogenase, E3 subunit of pyruvate dehydrogenase complex. | Lmo1734 protein; Similar to glutamate synthase (large subunit). | 0.941 |
PdhD | lmo2425 | gene:17593711 | gene:17595135 | Highly similar to dihydrolipoamide dehydrogenase, E3 subunit of pyruvate dehydrogenase complex. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.971 |
PdhD | lmo2566 | gene:17593711 | gene:17595277 | Highly similar to dihydrolipoamide dehydrogenase, E3 subunit of pyruvate dehydrogenase complex. | Lipoyl-[GcvH]:protein N-lipoyltransferase; Catalyzes the amidotransfer (transamidation) of the lipoyl moiety from lipoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes. Takes part in a pathway for scavenging of lipoic acid derived from eukaryotic host cells. Cannot use lipoyl- tripeptide (DK(L)A), lipoamide (LD), or free lipoate as substrate. Belongs to the octanoyltransferase LipL family. | 0.626 |
glyA | PdhD | gene:17595250 | gene:17593711 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Highly similar to dihydrolipoamide dehydrogenase, E3 subunit of pyruvate dehydrogenase complex. | 0.905 |
glyA | lmo1348 | gene:17595250 | gene:17594005 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.998 |
glyA | lmo1349 | gene:17595250 | gene:17594006 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Probable glycine dehydrogenase (decarboxylating) subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.980 |
glyA | lmo1350 | gene:17595250 | gene:17594007 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Probable glycine dehydrogenase (decarboxylating) subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.986 |
glyA | lmo1371 | gene:17595250 | gene:17594028 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Dihydrolipoyl dehydrogenase; Similar to branched-chain alpha-keto acid dehydrogenase E3 subunit. | 0.907 |
glyA | lmo1734 | gene:17595250 | gene:17594416 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Lmo1734 protein; Similar to glutamate synthase (large subunit). | 0.939 |
glyA | lmo2425 | gene:17595250 | gene:17595135 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.985 |
lmo0764 | PdhD | gene:17593415 | gene:17593711 | Similar to lipoate-protein ligase. | Highly similar to dihydrolipoamide dehydrogenase, E3 subunit of pyruvate dehydrogenase complex. | 0.833 |
lmo0764 | lmo0931 | gene:17593415 | gene:17593586 | Similar to lipoate-protein ligase. | Similar to lipoate protein ligase A. | 0.947 |
lmo0764 | lmo1371 | gene:17593415 | gene:17594028 | Similar to lipoate-protein ligase. | Dihydrolipoyl dehydrogenase; Similar to branched-chain alpha-keto acid dehydrogenase E3 subunit. | 0.765 |