vorB protein (Bathyarchaeota archaeon BA1) - STRING interaction network

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Score

vorB

Ketoisovalerate oxidoreductase subunit VorB. (354 aa)

Predicted Functional Partners:

vorA_1

0.999

vorA_2

0.999

korB

0.999

vorC_1

0.997

korC

0.996

porB_1

0.991

porB_2

0.991

sucC

0.983

vorC_2

0.980

AOA65_1525

0.980

Your Current Organism:

Bathyarchaeota archaeon BA1

NCBI taxonomy Id: 1700835
Other names: C. Bathyarchaeota archaeon BA1, Candidatus Bathyarchaeota archaeon BA1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AOA65_1525	korB	AOA65_1525	AOA65_1109	Acyl-CoA synthetase (NDP forming); Similarity search against UniProtKB Archaea.	2-oxoglutarate synthase subunit KorB.	0.966
AOA65_1525	korC	AOA65_1525	AOA65_1108	Acyl-CoA synthetase (NDP forming); Similarity search against UniProtKB Archaea.	2-oxoglutarate synthase subunit KorC.	0.640
AOA65_1525	porB_1	AOA65_1525	AOA65_1938	Acyl-CoA synthetase (NDP forming); Similarity search against UniProtKB Archaea.	Pyruvate synthase subunit PorB.	0.881
AOA65_1525	porB_2	AOA65_1525	AOA65_2216	Acyl-CoA synthetase (NDP forming); Similarity search against UniProtKB Archaea.	Pyruvate synthase subunit PorB.	0.881
AOA65_1525	sucC	AOA65_1525	AOA65_0639	Acyl-CoA synthetase (NDP forming); Similarity search against UniProtKB Archaea.	succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.847
AOA65_1525	vorA_1	AOA65_1525	AOA65_1039	Acyl-CoA synthetase (NDP forming); Similarity search against UniProtKB Archaea.	Ketoisovalerate oxidoreductase subunit VorA.	0.640
AOA65_1525	vorA_2	AOA65_1525	AOA65_1040	Acyl-CoA synthetase (NDP forming); Similarity search against UniProtKB Archaea.	Ketoisovalerate oxidoreductase subunit VorA.	0.962
AOA65_1525	vorB	AOA65_1525	AOA65_1041	Acyl-CoA synthetase (NDP forming); Similarity search against UniProtKB Archaea.	Ketoisovalerate oxidoreductase subunit VorB.	0.980
korB	AOA65_1525	AOA65_1109	AOA65_1525	2-oxoglutarate synthase subunit KorB.	Acyl-CoA synthetase (NDP forming); Similarity search against UniProtKB Archaea.	0.966
korB	korC	AOA65_1109	AOA65_1108	2-oxoglutarate synthase subunit KorB.	2-oxoglutarate synthase subunit KorC.	0.999
korB	porB_1	AOA65_1109	AOA65_1938	2-oxoglutarate synthase subunit KorB.	Pyruvate synthase subunit PorB.	0.832
korB	porB_2	AOA65_1109	AOA65_2216	2-oxoglutarate synthase subunit KorB.	Pyruvate synthase subunit PorB.	0.832
korB	sucC	AOA65_1109	AOA65_0639	2-oxoglutarate synthase subunit KorB.	succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.988
korB	vorA_1	AOA65_1109	AOA65_1039	2-oxoglutarate synthase subunit KorB.	Ketoisovalerate oxidoreductase subunit VorA.	0.999
korB	vorA_2	AOA65_1109	AOA65_1040	2-oxoglutarate synthase subunit KorB.	Ketoisovalerate oxidoreductase subunit VorA.	0.996
korB	vorB	AOA65_1109	AOA65_1041	2-oxoglutarate synthase subunit KorB.	Ketoisovalerate oxidoreductase subunit VorB.	0.999
korB	vorC_1	AOA65_1109	AOA65_1042	2-oxoglutarate synthase subunit KorB.	Ketoisovalerate oxidoreductase subunit VorC.	0.979
korB	vorC_2	AOA65_1109	AOA65_1111	2-oxoglutarate synthase subunit KorB.	Ketoisovalerate oxidoreductase subunit VorC.	0.995
korC	AOA65_1525	AOA65_1108	AOA65_1525	2-oxoglutarate synthase subunit KorC.	Acyl-CoA synthetase (NDP forming); Similarity search against UniProtKB Archaea.	0.640
korC	korB	AOA65_1108	AOA65_1109	2-oxoglutarate synthase subunit KorC.	2-oxoglutarate synthase subunit KorB.	0.999

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Network Stats

number of nodes:

11

number of edges:

18

average node degree:

3.27

avg. local clustering coefficient:

0.84

expected number of edges:

14

PPI enrichment p-value:

0.171

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006457

Protein folding

7 of 12

2.23

4.91

2.61e-11

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051082

Unfolded protein binding

6 of 7

2.4

4.72

3.09e-10

GO:0140662

ATP-dependent protein folding chaperone

4 of 5

2.37

2.96

1.89e-06

GO:0005515

Protein binding

7 of 42

1.69

2.89

1.15e-08

GO:0140657

ATP-dependent activity

6 of 141

1.1

1.03

0.00026

GO:0017076

Purine nucleotide binding

9 of 395

0.83

0.78

3.69e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 1054

0.45

0.33

0.0113

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:407

Protein folding, and Clp protease

9 of 12

2.34

7.19

1.14e-16

CL:402

Mixed, incl. Chaperone, and Protein catabolic process

10 of 28

2.02

5.94

1.14e-16

CL:409

Stress response, and Clp protease

5 of 6

2.39

4.05

9.10e-09

CL:80

Mixed, incl. Translation, and Chaperone

11 of 189

1.23

1.98

7.27e-12

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0143

Chaperone

6 of 15

2.07

3.83

3.17e-09

KW-0346

Stress response

5 of 8

2.26

3.77

2.04e-08

KW-0677

Repeat

2 of 11

1.73

0.71

0.0414

KW-0963

Cytoplasm

6 of 232

0.88

0.67

0.0034

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