STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
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[Homology]
Score
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (377 aa)    
Predicted Functional Partners:
dnaK
Chaperone dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 0.991
AMK54487.1
Pyruvate:ferredoxin (flavodoxin) oxidoreductase; 'Pfam: Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg; Pfam: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; SMART: Domain of unknown function; Pfam: Pyruvate ferredoxin/flavodoxin oxidoreductase; Pfam: Domain of unknown function; TIGRFAM: pyruv_ox_red: pyruvate:ferredoxin (flavodoxin) oxidoreductase; Pfam: 4Fe-4S dicluster domain'.
  
 
 0.987
grpE
Hypothetical protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dep [...]
 
 
 0.931
htpG
Hypothetical protein; Molecular chaperone. Has ATPase activity.
  
 0.875
AMK54710.1
ATP-dependent chaperone ClpB; 'SMART: C-terminal, D2-small domain, of ClpB protein; SMART: ATPases associated with a variety of cellular activities; Pfam: AAA domain (Cdc48 subfamily); Pfam: ATPase family associated with various cellular activities (AAA); PRINTS: ATP-dependent Clp protease ATP-binding subunit signature; Pfam: C-terminal, D2-small domain, of ClpB protein'; Belongs to the ClpA/ClpB family.
  
 
 0.754
rplN
50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family.
  
 
 0.729
rplC
50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.
  
 
 0.722
AMK54037.1
Hypothetical protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family.
 
 0.713
AMK55184.1
Hypothetical protein; 'Pfam: Methyltransferase domain; SMART: helix_turn_helix, mercury resistance; Pfam: MerR HTH family regulatory protein'.
  
 
 0.700
AMK53615.1
50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
  
 
 0.688
Your Current Organism:
Faecalibaculum rodentium
NCBI taxonomy Id: 1702221
Other names: Allobaculum sp. Alo17, Erysipelotrichaceae bacterium Alo17, F. rodentium, Faecalibaculum rodentium Chang et al. 2016 emend. Cox et al. 2017, JCM 30274, KCTC 15484, strain ALO17
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