| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| csd | moeZ | AMD24_00380 | AMD24_00524 | Putative cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. | Putative adenylyltransferase/sulfurtransferase MoeZ. | 0.505 |
| csd | trxB | AMD24_00380 | AMD24_00068 | Putative cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. | Thioredoxin reductase. | 0.903 |
| ctaC | lpd | AMD24_00174 | AMD24_00120 | Cytochrome c oxidase subunit 2 precursor; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). | Dihydrolipoyl dehydrogenase. | 0.547 |
| ctaC | secD | AMD24_00174 | AMD24_00082 | Cytochrome c oxidase subunit 2 precursor; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). | Protein translocase subunit SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. | 0.531 |
| ctaC | trxB | AMD24_00174 | AMD24_00068 | Cytochrome c oxidase subunit 2 precursor; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). | Thioredoxin reductase. | 0.525 |
| dcd | trxB | AMD24_00067 | AMD24_00068 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Thioredoxin reductase. | 0.544 |
| glyA | lpd | AMD24_00614 | AMD24_00120 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | Dihydrolipoyl dehydrogenase. | 0.957 |
| glyA | lpxC | AMD24_00614 | AMD24_00077 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily. | 0.469 |
| glyA | moeZ | AMD24_00614 | AMD24_00524 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | Putative adenylyltransferase/sulfurtransferase MoeZ. | 0.760 |
| glyA | pheT | AMD24_00614 | AMD24_00862 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | Phenylalanine--tRNA ligase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.571 |
| glyA | secD | AMD24_00614 | AMD24_00082 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | Protein translocase subunit SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. | 0.482 |
| glyA | trxA | AMD24_00614 | AMD24_00463 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | Thioredoxin-1; Belongs to the thioredoxin family. | 0.873 |
| glyA | trxB | AMD24_00614 | AMD24_00068 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | Thioredoxin reductase. | 0.534 |
| lpd | ctaC | AMD24_00120 | AMD24_00174 | Dihydrolipoyl dehydrogenase. | Cytochrome c oxidase subunit 2 precursor; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). | 0.547 |
| lpd | glyA | AMD24_00120 | AMD24_00614 | Dihydrolipoyl dehydrogenase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | 0.957 |
| lpd | moeZ | AMD24_00120 | AMD24_00524 | Dihydrolipoyl dehydrogenase. | Putative adenylyltransferase/sulfurtransferase MoeZ. | 0.478 |
| lpd | pheT | AMD24_00120 | AMD24_00862 | Dihydrolipoyl dehydrogenase. | Phenylalanine--tRNA ligase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.536 |
| lpd | trxA | AMD24_00120 | AMD24_00463 | Dihydrolipoyl dehydrogenase. | Thioredoxin-1; Belongs to the thioredoxin family. | 0.582 |
| lpd | trxB | AMD24_00120 | AMD24_00068 | Dihydrolipoyl dehydrogenase. | Thioredoxin reductase. | 0.498 |
| lpxC | glyA | AMD24_00077 | AMD24_00614 | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | 0.469 |
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