| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| glyA | guaA | AMD24_00614 | AMD24_00593 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.688 |
| glyA | pstB | AMD24_00614 | AMD24_00618 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | Phosphate import ATP-binding protein PstB; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. | 0.480 |
| glyA | ribBA | AMD24_00614 | AMD24_00707 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | Riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.728 |
| guaA | glyA | AMD24_00593 | AMD24_00614 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | 0.688 |
| guaA | pstA | AMD24_00593 | AMD24_00619 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Phosphate transport system permease protein PstA. | 0.506 |
| guaA | pstB | AMD24_00593 | AMD24_00618 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Phosphate import ATP-binding protein PstB; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. | 0.528 |
| guaA | pstS | AMD24_00593 | AMD24_00621 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Phosphate-binding protein PstS precursor; Belongs to the PstS family. | 0.513 |
| guaA | ribBA | AMD24_00593 | AMD24_00707 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.657 |
| lolD | mshA | AMD24_00622 | AMD24_00624 | Lipoprotein-releasing system ATP-binding protein LolD. | D-inositol 3-phosphate glycosyltransferase. | 0.574 |
| lolD | phoU | AMD24_00622 | AMD24_00617 | Lipoprotein-releasing system ATP-binding protein LolD. | Phosphate-specific transport system accessory protein PhoU; Plays a role in the regulation of phosphate uptake. | 0.516 |
| lolD | pstA | AMD24_00622 | AMD24_00619 | Lipoprotein-releasing system ATP-binding protein LolD. | Phosphate transport system permease protein PstA. | 0.567 |
| lolD | pstB | AMD24_00622 | AMD24_00618 | Lipoprotein-releasing system ATP-binding protein LolD. | Phosphate import ATP-binding protein PstB; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. | 0.857 |
| lolD | pstC | AMD24_00622 | AMD24_00620 | Lipoprotein-releasing system ATP-binding protein LolD. | Phosphate transport system permease protein PstC; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. | 0.577 |
| lolD | pstS | AMD24_00622 | AMD24_00621 | Lipoprotein-releasing system ATP-binding protein LolD. | Phosphate-binding protein PstS precursor; Belongs to the PstS family. | 0.566 |
| mshA | lolD | AMD24_00624 | AMD24_00622 | D-inositol 3-phosphate glycosyltransferase. | Lipoprotein-releasing system ATP-binding protein LolD. | 0.574 |
| mshA | pstA | AMD24_00624 | AMD24_00619 | D-inositol 3-phosphate glycosyltransferase. | Phosphate transport system permease protein PstA. | 0.407 |
| mshA | pstB | AMD24_00624 | AMD24_00618 | D-inositol 3-phosphate glycosyltransferase. | Phosphate import ATP-binding protein PstB; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. | 0.407 |
| mshA | pstC | AMD24_00624 | AMD24_00620 | D-inositol 3-phosphate glycosyltransferase. | Phosphate transport system permease protein PstC; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. | 0.407 |
| mshA | pstS | AMD24_00624 | AMD24_00621 | D-inositol 3-phosphate glycosyltransferase. | Phosphate-binding protein PstS precursor; Belongs to the PstS family. | 0.407 |
| phoU | lolD | AMD24_00617 | AMD24_00622 | Phosphate-specific transport system accessory protein PhoU; Plays a role in the regulation of phosphate uptake. | Lipoprotein-releasing system ATP-binding protein LolD. | 0.516 |