AMQ22_02046 protein (Methanofastidiosum methylthiophilus)

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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[Homology]

Score

AMQ22_02046

Catalase-related immune-responsive. (494 aa)

Predicted Functional Partners:

AMQ22_01028

0.827

AMQ22_01763

0.816

APG08_00030

0.783

APG08_01533

0.783

AMQ22_01762

0.738

APG08_00023

0.708

AMQ22_00719

0.695

AMQ22_02031

0.695

AMQ22_02028

0.679

APG08_01464

0.679

Your Current Organism:

Methanofastidiosum methylthiophilus

NCBI taxonomy Id: 1705564
Other names: Arc I group archaeon ADurb1013_Bin02101, Arc I group archaeon ADurb1113_Bin01801, Arc I group archaeon ADurb1213_Bin02801, Arc I group archaeon B03fssc0709_Meth_Bin005, Arc I group archaeon B15fssc0709_Meth_Bin003, Arc I group archaeon BMIXfssc0709_Meth_Bin006, Arc I group archaeon U1lsi0528_Bin055, Arc I group archaeon U1lsi0528_Bin089, C. Methanofastidiosum methylthiophilus, Ca. Methanofastidiosum methylthiophilus, Candidatus Methanofastidiosum methylthiophilus, WSA2 group archaeon U1lsi0528_Bin055, WSA2 group archaeon U1lsi0528_Bin089

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMQ22_00719	AMQ22_01762	APG08_00594	APG08_00070	Lactaldehyde dehydrogenase.	Hydrogenase MvhADGHdrABC CoB-CoM heterodisulfide reductase subunit B.	0.758
AMQ22_00719	AMQ22_01763	APG08_00594	APG08_00071	Lactaldehyde dehydrogenase.	Glycolate oxidase subunit GlcD.	0.768
AMQ22_00719	AMQ22_02046	APG08_00594	APG08_00364	Lactaldehyde dehydrogenase.	Catalase-related immune-responsive.	0.695
AMQ22_00719	APG08_00030	APG08_00594	APG08_00030	Lactaldehyde dehydrogenase.	annotation not available	0.558
AMQ22_00719	APG08_01533	APG08_00594	APG08_01533	Lactaldehyde dehydrogenase.	annotation not available	0.558
AMQ22_01028	AMQ22_02028	APG08_00460	APG08_01075	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.	Ferric uptake regulator.	0.626
AMQ22_01028	AMQ22_02046	APG08_00460	APG08_00364	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.	Catalase-related immune-responsive.	0.827
AMQ22_01028	APG08_00030	APG08_00460	APG08_00030	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.	annotation not available	0.561
AMQ22_01028	APG08_01464	APG08_00460	APG08_01464	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.	annotation not available	0.626
AMQ22_01028	APG08_01533	APG08_00460	APG08_01533	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.	annotation not available	0.561
AMQ22_01762	AMQ22_00719	APG08_00070	APG08_00594	Hydrogenase MvhADGHdrABC CoB-CoM heterodisulfide reductase subunit B.	Lactaldehyde dehydrogenase.	0.758
AMQ22_01762	AMQ22_01763	APG08_00070	APG08_00071	Hydrogenase MvhADGHdrABC CoB-CoM heterodisulfide reductase subunit B.	Glycolate oxidase subunit GlcD.	0.979
AMQ22_01762	AMQ22_02031	APG08_00070	APG08_01437	Hydrogenase MvhADGHdrABC CoB-CoM heterodisulfide reductase subunit B.	Lactaldehyde dehydrogenase.	0.745
AMQ22_01762	AMQ22_02046	APG08_00070	APG08_00364	Hydrogenase MvhADGHdrABC CoB-CoM heterodisulfide reductase subunit B.	Catalase-related immune-responsive.	0.738
AMQ22_01762	APG08_00030	APG08_00070	APG08_00030	Hydrogenase MvhADGHdrABC CoB-CoM heterodisulfide reductase subunit B.	annotation not available	0.595
AMQ22_01762	APG08_01533	APG08_00070	APG08_01533	Hydrogenase MvhADGHdrABC CoB-CoM heterodisulfide reductase subunit B.	annotation not available	0.595
AMQ22_01763	AMQ22_00719	APG08_00071	APG08_00594	Glycolate oxidase subunit GlcD.	Lactaldehyde dehydrogenase.	0.768
AMQ22_01763	AMQ22_01762	APG08_00071	APG08_00070	Glycolate oxidase subunit GlcD.	Hydrogenase MvhADGHdrABC CoB-CoM heterodisulfide reductase subunit B.	0.979
AMQ22_01763	AMQ22_02028	APG08_00071	APG08_01075	Glycolate oxidase subunit GlcD.	Ferric uptake regulator.	0.594
AMQ22_01763	AMQ22_02031	APG08_00071	APG08_01437	Glycolate oxidase subunit GlcD.	Lactaldehyde dehydrogenase.	0.773

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Network Stats

number of nodes:

8

number of edges:

14

average node degree:

3.5

avg. local clustering coefficient:

0.875

expected number of edges:

7

PPI enrichment p-value:

0.016

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015628

Protein secretion by the type II secretion system

2 of 14

2.16

0.98

0.0224

GO:0071806

Protein transmembrane transport

3 of 49

1.79

0.93

0.0224

GO:0009306

Protein secretion

3 of 62

1.69

0.9

0.0224

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015627

Type II protein secretion system complex

2 of 9

2.35

1.27

0.0074

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11743

Mostly uncharacterized, incl. Type II secretion system (T2SS), protein G, and Dioxygenase

5 of 29

2.24

3.75

9.74e-08

CL:11777

Mostly uncharacterized, incl. Cytosolic ribosome, and Peptidase family S41

3 of 12

2.4

2.21

0.00017

CL:11779

Mixed, incl. Tryptophan 2,3-dioxygenase, and Nuclease, putative, TT1808

2 of 5

2.6

1.27

0.0080

CL:11747

Mixed, incl. Type II secretion system (T2SS), protein G, and protein-(glutamine-N5) methyltransferase activity

2 of 6

2.52

1.25

0.0085

CL:10864

Type II protein secretion system complex, and NolW-like

2 of 7

2.46

1.23

0.0091

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ccx03070

Bacterial secretion system

4 of 48

1.92

2.47

1.28e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08334

Type II secretion system (T2SS), protein G

3 of 5

2.78

2.69

3.37e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013545

Type II secretion system protein GspG, C-terminal

3 of 5

2.78

2.46

8.32e-05

IPR045584

Pilin-like

3 of 11

2.44

2.1

0.00027

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