node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SEI55595.1 | SEJ21585.1 | SAMN04244579_01133 | SAMN04244579_03520 | (S)-citramalyl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | 0.690 |
SEI55595.1 | tpiA | SAMN04244579_01133 | SAMN04244579_04797 | (S)-citramalyl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.415 |
SEI60584.1 | SEJ21585.1 | SAMN04244579_01337 | SAMN04244579_03520 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | 0.531 |
SEI60584.1 | mtnA | SAMN04244579_01337 | SAMN04244579_01639 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.825 |
SEI60584.1 | mtnD | SAMN04244579_01337 | SAMN04244579_02458 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Acireductone dioxygenase apoprotein; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. | 0.708 |
SEI62164.1 | SEJ21585.1 | SAMN04244579_01406 | SAMN04244579_03520 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | 0.508 |
SEI62164.1 | glpK | SAMN04244579_01406 | SAMN04244579_02847 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. | 0.416 |
SEI62164.1 | tpiA | SAMN04244579_01406 | SAMN04244579_04797 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.870 |
SEI66264.1 | SEJ21585.1 | SAMN04244579_01563 | SAMN04244579_03520 | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | 0.543 |
SEI66264.1 | mtnA | SAMN04244579_01563 | SAMN04244579_01639 | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.977 |
SEI66264.1 | mtnD | SAMN04244579_01563 | SAMN04244579_02458 | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Acireductone dioxygenase apoprotein; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. | 0.442 |
SEJ21585.1 | SEI55595.1 | SAMN04244579_03520 | SAMN04244579_01133 | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | (S)-citramalyl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. | 0.690 |
SEJ21585.1 | SEI60584.1 | SAMN04244579_03520 | SAMN04244579_01337 | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.531 |
SEJ21585.1 | SEI62164.1 | SAMN04244579_03520 | SAMN04244579_01406 | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | 0.508 |
SEJ21585.1 | SEI66264.1 | SAMN04244579_03520 | SAMN04244579_01563 | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | 0.543 |
SEJ21585.1 | SEJ48854.1 | SAMN04244579_03520 | SAMN04244579_04571 | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | Transketolase. | 0.508 |
SEJ21585.1 | glpK | SAMN04244579_03520 | SAMN04244579_02847 | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. | 0.502 |
SEJ21585.1 | mtnA | SAMN04244579_03520 | SAMN04244579_01639 | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.648 |
SEJ21585.1 | mtnC | SAMN04244579_03520 | SAMN04244579_02457 | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. | 0.533 |
SEJ21585.1 | mtnD | SAMN04244579_03520 | SAMN04244579_02458 | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | Acireductone dioxygenase apoprotein; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. | 0.663 |