node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SEI55595.1 | SEJ37509.1 | SAMN04244579_01133 | SAMN04244579_04125 | (S)-citramalyl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | 0.732 |
SEI55595.1 | SEJ39213.1 | SAMN04244579_01133 | SAMN04244579_04185 | (S)-citramalyl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | 0.727 |
SEI55595.1 | tpiA | SAMN04244579_01133 | SAMN04244579_04797 | (S)-citramalyl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.415 |
SEI60584.1 | SEJ37509.1 | SAMN04244579_01337 | SAMN04244579_04125 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | 0.531 |
SEI60584.1 | SEJ39213.1 | SAMN04244579_01337 | SAMN04244579_04185 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | 0.531 |
SEI60584.1 | mtnA | SAMN04244579_01337 | SAMN04244579_01639 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.825 |
SEI60584.1 | mtnD | SAMN04244579_01337 | SAMN04244579_02458 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Acireductone dioxygenase apoprotein; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. | 0.708 |
SEI66264.1 | SEJ37509.1 | SAMN04244579_01563 | SAMN04244579_04125 | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | 0.590 |
SEI66264.1 | SEJ39213.1 | SAMN04244579_01563 | SAMN04244579_04185 | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | 0.543 |
SEI66264.1 | mtnA | SAMN04244579_01563 | SAMN04244579_01639 | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.977 |
SEI66264.1 | mtnD | SAMN04244579_01563 | SAMN04244579_02458 | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Acireductone dioxygenase apoprotein; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. | 0.442 |
SEJ37509.1 | SEI55595.1 | SAMN04244579_04125 | SAMN04244579_01133 | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | (S)-citramalyl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. | 0.732 |
SEJ37509.1 | SEI60584.1 | SAMN04244579_04125 | SAMN04244579_01337 | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.531 |
SEJ37509.1 | SEI66264.1 | SAMN04244579_04125 | SAMN04244579_01563 | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | 0.590 |
SEJ37509.1 | SEJ39213.1 | SAMN04244579_04125 | SAMN04244579_04185 | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | 0.525 |
SEJ37509.1 | mtnA | SAMN04244579_04125 | SAMN04244579_01639 | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.821 |
SEJ37509.1 | mtnC | SAMN04244579_04125 | SAMN04244579_02457 | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. | 0.755 |
SEJ37509.1 | mtnD | SAMN04244579_04125 | SAMN04244579_02458 | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | Acireductone dioxygenase apoprotein; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. | 0.750 |
SEJ37509.1 | tpiA | SAMN04244579_04125 | SAMN04244579_04797 | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.693 |
SEJ39197.1 | SEJ39213.1 | SAMN04244579_04184 | SAMN04244579_04185 | Sulfonate transport system permease protein. | Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase. | 0.524 |