Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
comBTransport protein ComB; Required for induction of competence; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (449 aa)    
Predicted Functional Partners:
comA
Transport ATP-binding protein ComA; Required for induction of competence. Seems to transport the competence-stimulating peptide (CSP) (By similarity); Belongs to the ABC transporter superfamily. HlyB family.
 
 
 0.961
comE
Response regulator; Required for induction of competence.
     
 0.891
comD
Histidine protein kinase; Required for induction of competence.
 
   
 0.850
spr0468
Conserved hypothetical protein, truncation; blpA.
 
 
 0.849
spr0469
Conserved hypothetical protein, truncation; blpA.
 
 
 0.842
spr0106
Transporter, truncation; Similar to competence factor transporting ATP-binding/permease protein ComA.
 
 
 0.764
pncP
ABC transporter ATP binding protein - unknown substrate.
   
  
 0.619
clyB
ABC transporter ATP-binding/membrane-spanning - hemolysin secretion protein.
 
 
 0.603
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthetase; Belongs to the SAICAR synthetase family.
  
  
 0.601
blpT
Hypothetical protein.
      
 0.601
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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