node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
imdH | purC | spr2033 | spr0045 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylaminoimidazole-succinocarboxamide synthetase; Belongs to the SAICAR synthetase family. | 0.793 |
imdH | purD | spr2033 | spr0052 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylglycinamide synthetase. | 0.859 |
imdH | purE | spr2033 | spr0053 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.791 |
imdH | purF | spr2033 | spr0047 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Amidophosphoribosyl transferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.842 |
imdH | purH | spr2033 | spr0051 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.993 |
imdH | purK | spr2033 | spr0054 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosyl glucinamide formyltransferase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | 0.707 |
imdH | purL | spr2033 | spr0046 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylformylglycinamide synthetase. | 0.938 |
imdH | purM | spr2033 | spr0048 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylaminoimidazole synthetase. | 0.918 |
imdH | purN | spr2033 | spr0049 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 5'-phosphoribosylglycinamide transformylase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.764 |
purC | imdH | spr0045 | spr2033 | Phosphoribosylaminoimidazole-succinocarboxamide synthetase; Belongs to the SAICAR synthetase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.793 |
purC | purD | spr0045 | spr0052 | Phosphoribosylaminoimidazole-succinocarboxamide synthetase; Belongs to the SAICAR synthetase family. | Phosphoribosylglycinamide synthetase. | 0.974 |
purC | purE | spr0045 | spr0053 | Phosphoribosylaminoimidazole-succinocarboxamide synthetase; Belongs to the SAICAR synthetase family. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.998 |
purC | purF | spr0045 | spr0047 | Phosphoribosylaminoimidazole-succinocarboxamide synthetase; Belongs to the SAICAR synthetase family. | Amidophosphoribosyl transferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.974 |
purC | purH | spr0045 | spr0051 | Phosphoribosylaminoimidazole-succinocarboxamide synthetase; Belongs to the SAICAR synthetase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.992 |
purC | purK | spr0045 | spr0054 | Phosphoribosylaminoimidazole-succinocarboxamide synthetase; Belongs to the SAICAR synthetase family. | Phosphoribosyl glucinamide formyltransferase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | 0.986 |
purC | purL | spr0045 | spr0046 | Phosphoribosylaminoimidazole-succinocarboxamide synthetase; Belongs to the SAICAR synthetase family. | Phosphoribosylformylglycinamide synthetase. | 0.996 |
purC | purM | spr0045 | spr0048 | Phosphoribosylaminoimidazole-succinocarboxamide synthetase; Belongs to the SAICAR synthetase family. | Phosphoribosylaminoimidazole synthetase. | 0.992 |
purC | purN | spr0045 | spr0049 | Phosphoribosylaminoimidazole-succinocarboxamide synthetase; Belongs to the SAICAR synthetase family. | 5'-phosphoribosylglycinamide transformylase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.957 |
purD | imdH | spr0052 | spr2033 | Phosphoribosylglycinamide synthetase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.859 |
purD | purC | spr0052 | spr0045 | Phosphoribosylglycinamide synthetase. | Phosphoribosylaminoimidazole-succinocarboxamide synthetase; Belongs to the SAICAR synthetase family. | 0.974 |