Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
trkATrk transporter NAD+ binding protein - K+ transport. (228 aa)    
Predicted Functional Partners:
trkH
Trk transporter membrane-spanning protein - K+ transport.
 
 
 0.997
fer
Ferredoxin.
      
 0.887
spr0069
Hypothetical protein.
       0.773
trkH-2
Trk transporter membrane-spanning protein - K+ transport.
  
 
 0.671
mscL
Large conductance mechano-sensitive ion channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
     
 0.643
basA
Gluthatione peroxidase; Belongs to the glutathione peroxidase family.
     
 0.609
sunL
rRNA methylase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
  
   0.534
lplA
Lipoate protein ligase A.
  
  
 0.527
greA
Transcription elongation factor GreA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
     
 0.485
cutC
Copper sensitivity; Participates in the control of copper homeostasis. Belongs to the CutC family.
      
 0.416
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
Server load: low (10%) [HD]