Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
ABC-NBDABC transporter ATP-binding protein - amino acid transport. (213 aa)    
Predicted Functional Partners:
ABC-MSP-3
ABC transporter membrane-spanning permease - amino acid transport.
    
  0.977
spr0695
Conserved hypothetical protein.
 
 0.963
ABC-SBP-2
ABC transporter solute-binding protein - amino acid transport.
   
  0.943
spr1496
Hypothetical protein.
  
 
 0.772
ABC-NBD-24
ABC transporter ATP-binding protein - unknown substrate.
  
   
 0.764
spr1826
Conserved hypothetical protein.
 
 
 0.740
ABC-NBD-20
ABC transporter ATP-binding protein - multidrug efflux.
  
     0.708
spr0098
Hypothetical protein.
       0.605
gcp
Secreted metalloendopeptidase Gcp; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family.
 
    0.596
ABC-NBD-25
ABC transporter ATP-binding protein - unknown substrate.
   
0.566
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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