Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (415 aa)    
Predicted Functional Partners:
argH
Arginine succinate lyase.
 
 
 0.999
arcB
Ornithine transcarbamoylase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
  
 
 0.995
carB
Carbamoylphosphate synthase (ammonia), heavy subunit.
 
 
 0.983
asnA
Aspartate--ammonia ligase (asparagine synthetase A).
   
 
 0.961
argR-2
Arginine repressor; Regulates arginine biosynthesis genes.
  
  
 0.936
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.925
ABC-SBP-2
ABC transporter solute-binding protein - amino acid transport.
  
  
 0.921
carA
Carbamoylphosphate synthase (glutamine-hydrolysing) light subunit; Belongs to the CarA family.
  
 
 0.917
pyrB
Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
 
 0.911
ansB
L-asparaginase (L-asparagine amidohydrolase).
   
 
 0.906
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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