Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
spr0108Conserved hypothetical protein; Similar to ComB protein. (450 aa)    
Predicted Functional Partners:
spr0106
Transporter, truncation; Similar to competence factor transporting ATP-binding/permease protein ComA.
 
 
 0.963
spr0105
Transporter, truncation.
 
 
 0.943
spr0107
Hypothetical protein.
  
    0.819
spr0469
Conserved hypothetical protein, truncation; blpA.
 
 
 0.593
clyB
ABC transporter ATP-binding/membrane-spanning - hemolysin secretion protein.
 
 
 0.561
comA
Transport ATP-binding protein ComA; Required for induction of competence. Seems to transport the competence-stimulating peptide (CSP) (By similarity); Belongs to the ABC transporter superfamily. HlyB family.
 
 
 0.558
spr0109
Hypothetical protein.
  
  
 0.555
spr0468
Conserved hypothetical protein, truncation; blpA.
 
 
 0.531
spr1496
Hypothetical protein.
  
  
 0.500
spr0695
Conserved hypothetical protein.
  
  
 0.439
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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